Schmitt P, Mayer M, Magneney S, Michelot R, Potier P
Institut de Chimie des Substances Naturelles, CNRS 91198, Gif sur Yvette, France.
Biochem Biophys Res Commun. 1988 Oct 14;156(1):323-7. doi: 10.1016/s0006-291x(88)80843-x.
Pentapeptides X-D.Trp-Phe-D.Trp-Leu-Y-NH2 (X = H, Boc, parahydroxyphenylacetyl, Y = Met,Leu,Nle,Phe) were tested as antagonists against Substance P and against a specific agonist of the muscular receptor of neurokinins on the guinea-pig ileum. Weak antagonist or agonist activities could be observed with the free or the Boc-protected pentapeptides whilst the acylated compounds could be compared favorably with the best antagonists already described.
