Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments, Faculté des Sciences et Technologies, University of Reunion Island , 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis Cedex 9, La Réunion, France.
J Nat Prod. 2014 Apr 25;77(4):818-23. doi: 10.1021/np4009283. Epub 2014 Mar 6.
Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 μM.
从马达加斯加海绵 Biemna laboutei 的 CH2Cl2-MeOH（1:1）提取物中进行化学分析，分离得到了 7 种新的三环生物碱，包括 netamines H-N（1-7），以及已知的 netamine G 和 mirabilins A、C 和 F。通过对 1D 和 2D NMR 光谱和 HRESIMS 数据的解析，确定了它们的结构。所有化合物都进行了针对 KB 细胞的细胞毒性和抗疟原虫活性评价。发现 netamine M（6）具有细胞毒性，IC50 值在微摩尔范围内，而 netamine K（4）对恶性疟原虫表现出活性，IC50 值为 2.4 μM。
