Makar Tapas K, Nimmagadda Vamshi K C, Trisler David, Bever Christopher T
1 Multiple Sclerosis Center of Excellence-East , Department of Veterans Affairs Maryland Health Care System, Baltimore, Maryland.
J Interferon Cytokine Res. 2014 Aug;34(8):641-7. doi: 10.1089/jir.2013.0160. Epub 2014 Mar 6.
Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine with neuroprotective properties that has been identified as a potential therapeutic agent for diseases of the central nervous system (CNS). The use of BDNF has been limited by a short serum half-life and poor penetration of the blood-brain barrier. To address this limitation we have explored cell-based approaches to delivery. We have used experimental allergic encephalomyelitis (EAE), an inflammatory disease of the CNS, as a model system. We engineered hematopoietic stem cells to produce BDNF to determine the feasibility and effectiveness of cell-based delivery of BDNF into the CNS in EAE. We review those studies here.
脑源性神经营养因子（BDNF）是一种具有神经保护特性的多效性细胞因子，已被确定为中枢神经系统（CNS）疾病的潜在治疗剂。BDNF的使用受到血清半衰期短和血脑屏障穿透性差的限制。为了解决这一限制，我们探索了基于细胞的递送方法。我们使用实验性自身免疫性脑脊髓炎（EAE），一种中枢神经系统的炎症性疾病，作为模型系统。我们对造血干细胞进行工程改造以产生BDNF，以确定在EAE中基于细胞的BDNF递送至中枢神经系统的可行性和有效性。我们在此回顾这些研究。
