Parnow Abdolhossein, Hafedh Muthanna, Tsunoda Ikuo, Patel Darpan I, Baker Julien S, Saeidi Ayoub, Bagchi Sovan, Sengupta Pallav, Dutta Sulagna, Łuszczki Edyta, Stolarczyk Artur, Oleksy Łukasz, Al Kiyumi Maisa Hamed, Laher Ismail, Zouhal Hassane
Department of Sport Biological Sciences, Physical Education and Sports Sciences Faculty, Razi University, Kermanshah, Iran.
Department of Exercise Physiology, General Directorate of Education Basrah, Basrah, Iraq.
Front Med (Lausanne). 2023 Mar 30;10:1143766. doi: 10.3389/fmed.2023.1143766. eCollection 2023.
Multiple sclerosis (MS) is associated with an impaired immune system that severely affects the spinal cord and brain, and which is marked by progressive inflammatory demyelination. Patients with MS may benefit from exercise training as a suggested course of treatment. The most commonly used animal models of studies on MS are experimental autoimmune/allergic encephalomyelitis (EAE) models. The present review intends to concisely discuss the interventions using EAE models to understand the effectiveness of exercise as treatment for MS patients and thereby provide clear perspective for future research and MS management. For the present literature review, relevant published articles on EAE animal models that reported the impacts of exercise on MS, were extracted from various databases. Existing literature support the concept that an exercise regimen can reduce the severity of some of the clinical manifestations of EAE, including neurological signs, motor function, pain, and cognitive deficits. Further results demonstrate the mechanisms of EAE suppression with information relating to the immune system, demyelination, regeneration, and exercise in EAE. The role for neurotrophic factors has also been investigated. Analyzing the existing reports, this literature review infers that EAE is a suitable animal model that can help researchers develop further understanding and treatments for MS. Besides, findings from previous animal studies supports the contention that exercise assists in ameliorating MS progression.
多发性硬化症（MS）与免疫系统受损有关，免疫系统受损会严重影响脊髓和大脑，其特征为进行性炎症性脱髓鞘。MS患者可能会从运动训练作为一种建议的治疗方案中受益。MS研究中最常用的动物模型是实验性自身免疫性/过敏性脑脊髓炎（EAE）模型。本综述旨在简要讨论使用EAE模型的干预措施，以了解运动作为MS患者治疗方法的有效性，从而为未来的研究和MS管理提供清晰的视角。对于本次文献综述，从各种数据库中提取了有关EAE动物模型的相关已发表文章，这些文章报告了运动对MS的影响。现有文献支持这样一种观点，即运动方案可以减轻EAE的一些临床表现的严重程度，包括神经体征、运动功能、疼痛和认知缺陷。进一步的结果展示了EAE抑制的机制，以及与EAE中的免疫系统、脱髓鞘、再生和运动相关的信息。神经营养因子的作用也已得到研究。通过分析现有报告，本综述推断EAE是一种合适的动物模型，有助于研究人员进一步了解MS并开发治疗方法。此外，先前动物研究的结果支持运动有助于改善MS进展这一论点。
