速发型过敏反应期间人体皮肤中前列腺素D2在体内和体外的释放
The release of prostaglandin D2 from human skin in vivo and in vitro during immediate allergic reactions.
作者信息
Barr R M, Koro O, Francis D M, Black A K, Numata T, Greaves M W
机构信息
Institute of Dermatology, United Medical School of Guys Hospital, St. Thomas's Hospital, London.
出版信息
Br J Pharmacol. 1988 Jul;94(3):773-80. doi: 10.1111/j.1476-5381.1988.tb11588.x.
Abstract
- The release of prostaglandin D2 (PGD2) during immediate allergic reactions in human skin was investigated in vivo and in vitro. 2. Skin exudates were collected from abraded sites on the thigh of atopic subjects sensitive to D. pteronyssinus antigen and from non-atopic control subjects. Challenge with antigen caused the release of PGD2 and histamine, but not PGE2, from the skin of the atopic subjects. The molar ratio of histamine to PGD2 was about 140:1. Control subjects were unresponsive. 3. PGD2 was released from passively sensitized human skin challenged with antigen in vitro. The time course was similar in vitro and in vivo. The ratio of histamine to PGD2 in vitro was 78:1. 4. The identities of the prostaglandins were confirmed by high performance liquid chromatography and radioimmunoassay to PGD2 and PGE2. 5. PGD2 is the major arachidonic acid cyclo-oxygenase product synthesized by human mast cells. It is pro-inflammatory in human skin but its functions as a mediator in immediate hypersensitivity reactions in human skin are not clear. The results of this study suggest that, relative to histamine, PGD2 contributes little to the oedema and erythema of immediate reactions in human skin.
摘要
- 对人体皮肤速发型过敏反应中前列腺素D2（PGD2）的释放进行了体内和体外研究。2. 从对粉尘螨抗原敏感的特应性受试者大腿擦伤部位以及非特应性对照受试者收集皮肤渗出液。用抗原激发后，特应性受试者皮肤释放PGD2和组胺，但不释放PGE2。组胺与PGD2的摩尔比约为140:1。对照受试者无反应。3. 在体外，用抗原激发被动致敏的人体皮肤可释放PGD2。其时间进程在体外和体内相似。体外组胺与PGD2的比例为78:1。4. 通过高效液相色谱和针对PGD2和PGE2的放射免疫测定法确认了前列腺素的身份。5. PGD2是人类肥大细胞合成的主要花生四烯酸环氧化酶产物。它在人体皮肤中具有促炎作用，但其在人体皮肤速发型超敏反应中作为介质的功能尚不清楚。本研究结果表明，相对于组胺，PGD2对人体皮肤速发型反应的水肿和红斑作用较小。
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