Dogra Sunil, Yadav Savita
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Int J Dermatol. 2014 May;53(5):525-38. doi: 10.1111/ijd.12365. Epub 2014 Mar 6.
Acitretin, an active metabolite of etretinate, is the most widely used systemic retinoid in the treatment of psoriasis. There are several unique characteristics of this drug, which set it apart from other options in the therapeutic armamentarium of psoriasis. It is highly efficacious as monotherapy in some specific clinical subtypes of psoriasis. It has dose-sparing effects when used as combination therapy with conventional systemic drugs as well as the biologics. It is a good option for long-term maintenance therapy. Side effects are common but usually mild and can be managed by its proper dosing and monitoring. With appropriate patient selection, gradual dose escalation, and patient counseling, we can deliver good results in psoriasis with this useful drug. This review gives a comprehensive recount of acitretin use in the present era of biologics in psoriasis.
阿维A是依曲替酯的活性代谢产物，是治疗银屑病时使用最广泛的系统性维甲酸类药物。该药物具有几个独特的特点，使其有别于银屑病治疗手段中的其他选择。在某些特定临床亚型的银屑病中，它作为单一疗法疗效显著。与传统系统性药物以及生物制剂联合使用时，它具有节省剂量的作用。它是长期维持治疗的一个良好选择。副作用很常见，但通常较轻，可通过适当的剂量调整和监测进行处理。通过适当的患者选择、逐渐增加剂量以及对患者进行咨询指导，我们可以使用这种有用的药物在银屑病治疗中取得良好效果。本综述全面介绍了在生物制剂时代阿维A在银屑病治疗中的应用情况。
