Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Dermatol Ther. 2018 Jan;31(1). doi: 10.1111/dth.12571. Epub 2017 Nov 1.
Psoriasis is a chronic inflammatory disease of the skin which can occur at any age-group. Psoriasis in childhood is not uncommon and has genetic susceptibility but usually, an environmental trigger such as infection is thought to initiate the disease process. Pediatric psoriasis has profound effects on both physical and psychosocial health of the patient. Treatment of mild psoriasis can be done with topical therapies but those which do not respond to topical therapies can be treated with phototherapy and systemic therapies. The use of systemic therapies in childhood is mainly based on the published data, case series, expert opinion and the experience as there is the lack of controlled trials in the age group. Based on the experience retinoids are probably the second line drugs for the treatment of pediatric psoriasis which do not respond to topical therapies and phototherapy. Using acitretin in a low dose and with proper physical examinations and laboratory investigations will reduce the hazard of potential serious adverse events. This article gives the review of the use of acitretin in pediatric psoriasis.
银屑病是一种可发生于任何年龄段的慢性炎症性皮肤病。儿童银屑病并不少见，具有遗传易感性，但通常认为环境触发因素如感染会引发疾病过程。儿科银屑病对患者的身心健康都有深远的影响。轻度银屑病可以通过局部治疗来治疗，但对于那些对局部治疗没有反应的患者，可以采用光疗和系统治疗。儿童中使用系统治疗主要基于已发表的数据、病例系列、专家意见和经验，因为该年龄段缺乏对照试验。根据经验，类视黄醇可能是治疗对局部治疗和光疗无反应的儿科银屑病的二线药物。使用阿维 A 酯的低剂量，并进行适当的体检和实验室检查，将降低潜在严重不良事件的风险。本文综述了阿维 A 酯在儿科银屑病中的应用。
