Faugstad Tone Maeland, Brantberg Anne, Blaas Harm-Gerd K, Vogt Christina
Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Prenat Diagn. 2014 Jun;34(6):570-6. doi: 10.1002/pd.4350. Epub 2014 Apr 2.
This study compares prenatal ultrasound examination and autopsy findings in fetuses and infants with gastroschisis and omphalocele.
Criteria for inclusion in the study were an autopsy of fetuses/infants with gastroschisis or omphalocele performed between January 1985 and December 2009 and a prenatal ultrasound examination performed in a tertiary referral center. The results were organized into five categories depending on the degree of agreement.
Of 11 cases with gastroschisis, only one was not detected at the prenatal ultrasound examination, and the rest had full agreement. Of 70 fetuses with omphalocele, two were not diagnosed at the prenatal ultrasound examination. Four (15%) had major autopsy findings not detected prenatally. The main diagnosis was correct in 64/70 (91%) and improved from 85% to 95% during this study period. The number of cases with major and minor autopsy findings not detected by ultrasound examination was reduced from 48% to 21%. Full agreement occurred in 46/70 (66%).
This study shows that the correlation between prenatal ultrasound findings and postmortem examination is good and has improved over time. Comparing full agreement during the first 10 years with the last 15 years showed an improvement (p = 0.05) for fetuses with omphalocele.
本研究比较腹裂和脐膨出胎儿及婴儿的产前超声检查结果与尸检结果。
纳入本研究的标准为1985年1月至2009年12月期间对腹裂或脐膨出胎儿/婴儿进行尸检，以及在三级转诊中心进行产前超声检查。根据一致程度将结果分为五类。
11例腹裂病例中，产前超声检查仅漏诊1例，其余结果完全一致。70例脐膨出胎儿中，产前超声检查未诊断出2例。4例（15%）有产前未检测到的主要尸检结果。64/70例（91%）的主要诊断正确，在本研究期间从85%提高到95%。超声检查未发现的主要和次要尸检结果的病例数从48%降至21%。46/70例（66%）结果完全一致。
本研究表明，产前超声检查结果与尸检结果之间的相关性良好，且随时间有所改善。比较前10年和后15年的完全一致情况，发现脐膨出胎儿有改善（p = 0.05）。
