Maior Gustavo Ithamar Souto, Mascena Guilherme Veras, Marquis Valéria Wanderley Pinto Brandão, Figueiredo Filho Carlos Alberto, Paz Alexandre Rolim da, Moura Líbia Cristina Rocha Vilela, Brandt Carlos Teixeira
Fellow PhD degree, Postgraduate Program in Tropical Medicine, Health Sciences Center, Universidade Federal de Pernambuco (UFPE), Recife-PE, Brazil. Acquisition and interpretation of data, manuscript writing.
Fellow PhD degree, Postgraduate Program in Surgery, Health Sciences Center, UFPE, Recife-PE, Brazil. Statistical analysis, critical revision.
Acta Cir Bras. 2018 Sep;33(9):744-752. doi: 10.1590/s0102-865020180090000002.
To investigate cardiac changes in young rats, whose mothers underwent autogenic fecal peritonitis, during organogenesis phase and to evaluate the role of intravenous administration of moxifloxacin and dexamethasone in preventing infection-related cardiac changes.
A prospective histomorphometric study was performed on 29 hearts of Wistar four-month old rats. Animals were divided into three groups: Negative Control Group (NCG) included 9 subjects from healthy mothers; Positive Control Group (PCG) included 10 subjects from mothers with fecal peritonitis (intra-abdominal injection of 10% autogenic fecal suspension in the gestational period) and did not receive any treatment; and Intervention Group (IG), with 10 animals whose infected mothers received moxifloxacin and dexamethasone treatment 24 hours after induction of fecal peritonitis.
Nuclear count was higher in the IG group as compared to PCG (p = 0.0016) and in NCG as compared to PCG (p = 0.0380). There was no significant difference in nuclear counts between NCG and IG.
Induced autogenic fecal peritonitis in pregnant Wistar rats determined myocardial changes in young rats that could be avoided by the early administration of intravenous moxifloxacin and dexamethasone.
