Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland.
Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland.
Reprod Biol. 2014 Mar;14(1):61-7. doi: 10.1016/j.repbio.2014.01.004. Epub 2014 Jan 17.
Cutaneous injury in the majority of vertebrate animals results in the formation of a scar in the post-injured area. Scar tissues, although beneficial for maintaining integrity of the post-wounded region often interferes with full recovery of injured tissues. The goal of wound-healing studies is to identify mechanisms to redirect reparative pathways from debilitating scar formation to regenerative pathways that lead to normal functionality. To perform such studies models of regeneration, which are rare in mammals, are required. In this review we discussed skin regenerative capabilities present in lower vertebrates and in models of skin scar-free healing in mammals, e.g. mammalian fetuses. However, we especially focused on the attributes of two unusual models of skin scar-free healing capabilities that occur in adult mammals, that is, those associated with nude, FOXN1-deficient mice and in wild-type African spiny mice.
在大多数脊椎动物中，皮肤损伤会导致受伤区域形成疤痕。疤痕组织虽然有益于维持受伤区域的完整性，但常常会干扰受伤组织的完全恢复。伤口愈合研究的目标是确定机制，将修复途径从有害的瘢痕形成重定向到导致正常功能的再生途径。为了进行此类研究，需要具有再生能力的模型，而哺乳动物中这种模型非常罕见。在本文综述中，我们讨论了低等脊椎动物的皮肤再生能力，以及哺乳动物中无瘢痕愈合的模型，例如哺乳动物胎儿。然而，我们特别关注两种在成年哺乳动物中发生的无瘢痕愈合能力的不寻常模型的特性，即与裸鼠、FOXN1 缺陷型小鼠和野生型非洲刺毛鼠相关的特性。
