Kelishadi Roya, Poursafa Parinaz
Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Environment Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Curr Probl Pediatr Adolesc Health Care. 2014 Mar;44(3):54-72. doi: 10.1016/j.cppeds.2013.12.005.
This article is a comprehensive review on developmental origins of health and disease regarding various factors related to the origins of cardiovascular diseases from early life. It presents a summary of the impacts of various factors such as epigenetics; gene-environment interaction; ethnic predisposition to cardiovascular diseases and their underlying risk factors; prenatal factors; fetal programming; maternal weight status and weight gain during pregnancy; type of feeding during infancy; growth pattern during childhood; obesity; stunting; socioeconomic status; dietary and physical activity habits; active, secondhand, and thirdhand smoking, as well as environmental factors including air pollution and global climate change on the development and progress of cardiovascular diseases and their risk factors. The importance of early identification of predisposing factors for cardiovascular diseases for primordial and primary prevention of cardiovascular diseases from early life is highlighted.
本文是一篇关于健康与疾病发育起源的综合综述，涉及与早期生活中心血管疾病起源相关的各种因素。它总结了多种因素的影响，如表观遗传学；基因-环境相互作用；心血管疾病的种族易感性及其潜在危险因素；产前因素；胎儿编程；孕期母亲体重状况和体重增加；婴儿期喂养方式；儿童期生长模式；肥胖；发育迟缓；社会经济地位；饮食和身体活动习惯；主动吸烟、二手烟和三手烟，以及包括空气污染和全球气候变化在内的环境因素对心血管疾病及其危险因素的发生和发展的影响。强调了早期识别心血管疾病易感因素对于从生命早期进行心血管疾病一级预防和初级预防的重要性。
