Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada and Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada and Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Cell Stem Cell. 2014 Mar 6;14(3):275-91. doi: 10.1016/j.stem.2014.02.006.
Genetic analyses have shaped much of our understanding of cancer. However, it is becoming increasingly clear that cancer cells display features of normal tissue organization, where cancer stem cells (CSCs) can drive tumor growth. Although often considered as mutually exclusive models to describe tumor heterogeneity, we propose that the genetic and CSC models of cancer can be harmonized by considering the role of genetic diversity and nongenetic influences in contributing to tumor heterogeneity. We offer an approach to integrating CSCs and cancer genetic data that will guide the field in interpreting past observations and designing future studies.
遗传分析已经极大地塑造了我们对于癌症的理解。然而，越来越明显的是，癌细胞表现出正常组织的特征，而癌症干细胞（CSC）能够驱动肿瘤生长。尽管通常被认为是描述肿瘤异质性的相互排斥的模型，但我们提出，通过考虑遗传多样性和非遗传因素在促成肿瘤异质性方面的作用，可以协调癌症的遗传和 CSC 模型。我们提供了一种整合 CSC 和癌症遗传数据的方法，该方法将指导该领域解释过去的观察结果并设计未来的研究。
