转移性干细胞：来源、微环境及关键通路
Metastatic stem cells: sources, niches, and vital pathways.
作者信息
Oskarsson Thordur, Batlle Eduard, Massagué Joan
机构信息
Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.
出版信息
Cell Stem Cell. 2014 Mar 6;14(3):306-21. doi: 10.1016/j.stem.2014.02.002.
Abstract
Metastasis is powered by disseminated cancer cells that re-create a full-fledged tumor in unwelcoming tissues, away from the primary site. How cancer cells moving from a tumor into the circulation manage to infiltrate distant organs and initiate metastatic growth is of interest to cancer biologists and clinical oncologists alike. Recent findings have started to define the sources, phenotypic properties, hosting niches, and signaling pathways that support the survival, self-renewal, dormancy, and reactivation of cancer cells that initiate metastasis: metastatic stem cells. By dissecting the biology of this process, vulnerabilities are being exposed that could be exploited to prevent metastasis.
摘要
转移是由播散的癌细胞驱动的，这些癌细胞会在远离原发部位的不友好组织中重新形成一个成熟的肿瘤。癌细胞如何从肿瘤进入循环系统，进而渗透到远处器官并启动转移生长，这是癌症生物学家和临床肿瘤学家都感兴趣的问题。最近的研究结果已开始明确支持启动转移的癌细胞（即转移性干细胞）的存活、自我更新、休眠和重新激活的来源、表型特性、宿主微环境及信号通路。通过剖析这一过程的生物学特性，人们发现了一些可以用来预防转移的薄弱环节。
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本文引用的文献
1
Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.胶质瘤血管周围微环境中的骨桥蛋白-CD44信号增强癌症干细胞表型并促进侵袭性肿瘤生长。
Cell Stem Cell. 2014 Mar 6;14(3):357-69. doi: 10.1016/j.stem.2014.01.005.
2
CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.CD44v6 是驱动结肠癌转移的组成性和重编程癌症干细胞的标志物。
Cell Stem Cell. 2014 Mar 6;14(3):342-56. doi: 10.1016/j.stem.2014.01.009.
3
Serpins promote cancer cell survival and vascular co-option in brain metastasis.丝氨酸蛋白酶抑制剂促进脑转移中的癌细胞存活和血管选择。
Cell. 2014 Feb 27;156(5):1002-16. doi: 10.1016/j.cell.2014.01.040.
4
Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts.乳腺癌干细胞在上皮和间充质状态之间转换，反映了它们正常对应物的特征。
Stem Cell Reports. 2013 Dec 27;2(1):78-91. doi: 10.1016/j.stemcr.2013.11.009. eCollection 2014 Jan 14.
5
Bidirectional developmental potential in reprogrammed cells with acquired pluripotency.具有获得多能性的重编程细胞中的双向发育潜能。
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6
Stimulus-triggered fate conversion of somatic cells into pluripotency.刺激触发体细胞的多能性命运转换。
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7
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8
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9
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10
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