Kawahara Yuta, Morimoto Akira, Onoue Akinori, Kashii Yoshifumi, Fukushima Noriyoshi, Gunji Yuji
Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan,
Eur J Pediatr. 2014 Aug;173(8):1107-10. doi: 10.1007/s00431-014-2292-8. Epub 2014 Mar 8.
Adrenocortical oncocytomas are rarely reported, occur almost exclusively in adults, and are mostly nonfunctional. Here, we report an interleukin-6 (IL-6)-producing adrenocortical oncocytoma in an 11-year-old girl presenting with fever, body weight loss, and increased levels of inflammatory markers and serum IL-6. Imaging studies revealed a 4-cm mass in the left adrenal gland. After complete resection, laboratory findings returned to normal. Histology was consistent with adrenocortical oncocytoma, and the tumor cells stained positive for IL-6.
IL-6-producing adrenocortical oncocytoma should be included in the differential diagnosis and imaging studies should be performed in patients presenting with persistent fever of unknown origin and high levels of inflammatory markers.
肾上腺皮质嗜酸性细胞瘤鲜有报道，几乎仅发生于成年人，且大多无功能。在此，我们报告一例11岁女孩患有产生白细胞介素-6（IL-6）的肾上腺皮质嗜酸性细胞瘤，该女孩出现发热、体重减轻以及炎症标志物和血清IL-6水平升高。影像学检查显示左肾上腺有一个4厘米的肿块。完整切除后，实验室检查结果恢复正常。组织学检查结果与肾上腺皮质嗜酸性细胞瘤一致，肿瘤细胞IL-6染色呈阳性。
产生IL-6的肾上腺皮质嗜酸性细胞瘤应列入鉴别诊断范畴，对于不明原因持续发热且炎症标志物水平高的患者应进行影像学检查。
