Oguni Kohei, Goshima Yukiko, Tatsushima Keita, Hayashida Michikata, Urakami Shinji, Ito Shinji, Yamazaki Yuto, Sasano Hironobu, Takeuchi Yasuhiro, Takeshita Akira
Department of Endocrinology and Metabolism, Toranomon Hospital, Japan.
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Intern Med. 2025 Aug 1;64(15):2350-2355. doi: 10.2169/internalmedicine.4599-24. Epub 2025 Feb 1.
A 16-year-old girl presented with a high fever that had persisted for more than 4 weeks. Computed tomography revealed a 4-cm mass in the left adrenal gland. Clinically, there were no obvious symptoms of adrenal hormone excess; however, serum interleukin-6 (IL-6) and C-reactive protein levels were significantly elevated. After laparoscopic left adrenalectomy, the fever subsided, and her IL-6 level normalized. The tumor was pathologically diagnosed as adrenocortical carcinoma (ACC), with a Weiss score of 5/9. The tumor cells were immunoreactive for IL-6. To our knowledge, this is the first case report of symptomatic IL-6-producing ACC that initially presented with a persistent fever.
一名16岁女孩出现持续4周以上的高热。计算机断层扫描显示左肾上腺有一个4厘米的肿块。临床上，没有明显的肾上腺激素过多症状；然而，血清白细胞介素-6（IL-6）和C反应蛋白水平显著升高。腹腔镜下左肾上腺切除术后，发热消退，她的IL-6水平恢复正常。肿瘤经病理诊断为肾上腺皮质癌（ACC），Weiss评分为5/9。肿瘤细胞对IL-6呈免疫反应。据我们所知，这是首例最初表现为持续发热的产生IL-6的有症状ACC病例报告。
