The Laboratory for Physical Activity and Exercise Intervention Research, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI.
Child Health Evaluation and Research Unit, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
J Pediatr. 2014 May;164(5):1085-1090.e1. doi: 10.1016/j.jpeds.2014.01.034. Epub 2014 Mar 6.
To examine the independent contributions of objectively measured sleep duration and fragmentation on cardiometabolic risk accumulation in free-living obese adolescents.
Characteristics of metabolic syndrome (waist circumference, mean arterial pressure, fasting high-density lipoprotein cholesterol, triglycerides, glucose) were measured in obese adolescents and standardized residuals (z-scores) were summed (inverse high-density lipoprotein cholesterol) to create a continuous cardiometabolic risk score (cMetScore), adjusted for age, sex, and race. Sleep and physical activity were objectively measured in habitual, free-living conditions for 7 days (SenseWear Pro3, BodyMedia, Pittsburgh, Pennsylvania; n = 37; 54% female, ages 11-17 years). Associations between sleep duration and cMetScore were assessed via multiple linear regression.
Body mass index, total sleep time, and sleep session length were each correlated with cMetScore (P < .05 all). Total sleep time was inversely and independently associated with cMetScore (r = -0.535, P = .001) and was the best independent predictor of metabolic risk.
Sleep duration inversely predicts cardiometabolic risk in obese adolescents, even when we controlled for various measures of physical activity, anthropometry, and adiposity. Further research should investigate the biological mechanism of this relationship and the potential treatment effect of sleep intervention in decreasing cardiometabolic risk in this population.
研究客观测量的睡眠时长和碎片化对自由生活肥胖青少年代谢风险积累的独立贡献。
对肥胖青少年进行代谢综合征特征（腰围、平均动脉压、空腹高密度脂蛋白胆固醇、甘油三酯、血糖）的测量，并对其进行标准化残差（z 分数）求和（反高密度脂蛋白胆固醇），以创建一个连续的代谢风险评分（cMetScore），并根据年龄、性别和种族进行调整。在 7 天的日常、自由生活条件下（SenseWear Pro3，BodyMedia，匹兹堡，宾夕法尼亚州；n = 37；54%为女性，年龄 11-17 岁），使用 SenseWear Pro3 臂戴式活动监测器客观测量睡眠和身体活动。通过多元线性回归评估睡眠时长与 cMetScore 之间的关系。
体重指数、总睡眠时间和睡眠时长均与 cMetScore 相关（均 P <.05）。总睡眠时间与 cMetScore 呈负相关且独立相关（r = -0.535，P =.001），是代谢风险的最佳独立预测因子。
即使我们控制了各种身体活动、人体测量和肥胖指标，睡眠时长仍与肥胖青少年的代谢风险呈负相关。进一步的研究应调查这种关系的生物学机制，以及睡眠干预在降低该人群代谢风险方面的潜在治疗效果。
