Kaar Jill L, Simon Stacey L, Schmiege Sarah J, Nadeau Kristen J, Kelsey Megan M
Department of Pediatrics, Division of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, 13123 East 16th Avenue, Box 265, Aurora, CO, 80045, USA.
Department of Pediatrics, Division of Pulmonology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, 13123 East 16th Avenue, Box 395, Aurora, CO, 80045, USA.
Curr Diab Rep. 2017 Jul;17(7):49. doi: 10.1007/s11892-017-0881-4.
One-third of US adolescents are obese, and related comorbidities exist in this population. Preventing early indicators of these diseases, such as insulin resistance (IR), may impact future morbidity and mortality. Interventions to date have only focused on diet or exercise. Additional targets to prevent disease are needed. This paper reviews the evidence in adolescents examining multiple health behaviors that have been associated with IR.
Health behaviors (i.e., diet, activity, sleep) have been individually examined as possible contributors to disease, but an understanding of the complex interplay between these behaviors is lacking. A better understanding of how multiple health behaviors contribute to IR in adolescents is needed. Future studies using both advanced statistical methodology and robust measures of each health behavior may facilitate better understanding of the impact of lifestyle factors on IR and guide intervention strategies to reduce the risk of disease.
美国三分之一的青少年肥胖，且该人群存在相关合并症。预防这些疾病的早期指标，如胰岛素抵抗（IR），可能会影响未来的发病率和死亡率。迄今为止的干预措施仅集中在饮食或运动方面。需要更多预防疾病的靶点。本文综述了有关青少年多种与胰岛素抵抗相关的健康行为的证据。
健康行为（即饮食、活动、睡眠）已被单独研究，作为可能导致疾病的因素，但对这些行为之间复杂的相互作用缺乏了解。需要更好地理解多种健康行为如何导致青少年胰岛素抵抗。未来使用先进统计方法和对每种健康行为进行可靠测量的研究，可能有助于更好地理解生活方式因素对胰岛素抵抗的影响，并指导干预策略以降低疾病风险。
