脑性瘫痪学龄前儿童身体成分根据功能能力的差异。
Differences in body composition according to functional ability in preschool-aged children with cerebral palsy.
机构信息
Children's Nutrition Research Centre, Queensland Children's Medical Research Institute, The University of Queensland, Old Milk Kitchen, Building 916, Cnr Fourth and Back Rds (Southern Annexe of Edith Cavell Building), Herston, QLD 4029, Australia; Queensland Cerebral Palsy and Rehabilitation Research Centre, School of Medicine, The University of Queensland, Level 7, Block 6, Royal Brisbane and Women's Hospital, Herston, QLD 4029, Australia.
Children's Nutrition Research Centre, Queensland Children's Medical Research Institute, The University of Queensland, Old Milk Kitchen, Building 916, Cnr Fourth and Back Rds (Southern Annexe of Edith Cavell Building), Herston, QLD 4029, Australia; Queensland Cerebral Palsy and Rehabilitation Research Centre, School of Medicine, The University of Queensland, Level 7, Block 6, Royal Brisbane and Women's Hospital, Herston, QLD 4029, Australia; Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, QLD, Australia; Department of Paediatric Rehabilitation, Royal Children's Hospital, Brisbane, QLD, Australia.
出版信息
Clin Nutr. 2015 Feb;34(1):140-5. doi: 10.1016/j.clnu.2014.02.007. Epub 2014 Feb 20.
BACKGROUND & AIMS: Altered body composition is evident in school children with cerebral palsy (CP). Fat free mass and fat mass amounts differ according to functional ability and compared to typically developing children (TDC). The extent to which body composition is altered in preschool-aged children with CP is unknown. We aimed to determine the fat free mass index (FFMI) and body fat percentage (BF%) of preschool-aged children with CP and investigate differences according to functional ability and compared to TDC.
METHODS
Eighty-five children with CP (68% male) of all functional abilities, motor types and distributions and 16 TDC (63% male) aged 1.4-5.1 years participated in this cross-sectional study. Body composition was determined via isotope dilution. Children with CP were classified into groups based on their Gross Motor Function Classification System (GMFCS) level. Statistical analyses were via ANOVA, ANCOVA, post-hoc Tukey HSD tests, independent t-tests and multiple regressions.
RESULTS
There were no significant differences in FFMI or BF% when comparing all children with CP to TDC. Children classified as GMFCS levels III, IV and V had significantly lower FFMI levels compared to children classified as GMFCS I and II (p < 0.05). Children of GMFCS IV and V had the highest mean (± SD) BF% of all children (24.6% (± 10.7%)), significantly higher than children of GMFCS I and II (18.6% (± 6.8%), p < 0.05).
CONCLUSIONS
Altered body composition is evident in preschool-aged children with CP, with a trend towards lower FFMI levels and greater BF% across functional ability levels from GMFCS I to V. Further research is required to determine optimal body composition parameters and investigate contributing factors.
CLINICAL TRIAL REGISTRY
Australian New Zealand Clinical Trials Registry (ANZCTR) number: ACTRN12611000616976.
背景与目的
脑瘫（CP）患儿的身体成分发生改变。去脂体重和脂肪量根据功能能力而有所不同，并与正常发育儿童（TDC）进行比较。CP 学龄前儿童的身体成分改变程度尚不清楚。我们旨在确定 CP 学龄前儿童的去脂体重指数（FFMI）和体脂百分比（BF％），并根据功能能力进行比较，与 TDC 进行比较。
方法
本横断面研究纳入了所有功能能力、运动类型和分布的 85 名 CP 儿童（68％为男性）和 16 名 TDC（63％为男性），年龄为 1.4-5.1 岁。通过同位素稀释法确定身体成分。根据粗大运动功能分类系统（GMFCS）水平对 CP 患儿进行分组。采用方差分析、协方差分析、事后 Tukey HSD 检验、独立 t 检验和多元回归进行统计学分析。
结果
与 TDC 相比，所有 CP 患儿的 FFMI 或 BF％均无显著差异。与 GMFCS 水平 I 和 II 相比，GMFCS 水平 III、IV 和 V 的患儿的 FFMI 水平显著降低（p＜0.05）。GMFCS 水平 IV 和 V 的患儿的平均（± SD）BF％最高（24.6％（± 10.7％）），显著高于 GMFCS 水平 I 和 II 的患儿（18.6％（± 6.8％），p＜0.05）。
结论
CP 学龄前儿童的身体成分发生改变，从 GMFCS I 到 V 功能能力水平，FFMI 水平呈下降趋势，BF％呈上升趋势。需要进一步研究以确定最佳身体成分参数，并探讨其影响因素。
临床试验注册号
澳大利亚新西兰临床试验注册中心（ANZCTR）编号：ACTRN12611000616976。
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