白细胞介素-6前馈环：肿瘤发生的驱动因素。
The IL-6 feed-forward loop: a driver of tumorigenesis.
作者信息
Chang Qing, Daly Laura, Bromberg Jacqueline
机构信息
Department of Medicine, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY, USA.
Department of Medicine, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY, USA; Weill Cornell Medical College (WCMC), New York, NY, USA.
出版信息
Semin Immunol. 2014 Feb;26(1):48-53. doi: 10.1016/j.smim.2014.01.007. Epub 2014 Mar 6.
IL-6 signaling plays a prominent role in tumorigenesis and metastasis. In this review we discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this signaling pathway. Although blockade of this pathway in pre-clinical models leads to a reduction in tumor growth and metastasis, its clinical success is less evident. Thus, identifying the features of tumors/patients that predict response to anti-IL6 therapy are needed.
白细胞介素-6信号传导在肿瘤发生和转移中起重要作用。在本综述中，我们讨论了描述该信号通路肿瘤内在和外在功能的最新证据。尽管在临床前模型中阻断该通路会导致肿瘤生长和转移减少，但其临床疗效尚不明显。因此，需要确定预测抗白细胞介素-6治疗反应的肿瘤/患者特征。
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