白细胞介素-6及相关细胞因子是炎症与癌症之间的关键纽带。
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer.
作者信息
Taniguchi Koji, Karin Michael
机构信息
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; UC San Diego Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
出版信息
Semin Immunol. 2014 Feb;26(1):54-74. doi: 10.1016/j.smim.2014.01.001. Epub 2014 Feb 16.
Inflammatory responses play pivotal roles in cancer development, including tumor initiation, promotion, progression, and metastasis. Cytokines are now recognized as important mediators linking inflammation and cancer, and are therefore potential therapeutic and preventive targets as well as prognostic factors. The interleukin (IL)-6 family of cytokines, especially IL-6 and IL-11, is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis. This review discusses molecular mechanisms linking the IL-6 cytokine family to solid malignancies and their treatment.
炎症反应在癌症发展过程中发挥着关键作用，包括肿瘤的起始、促进、进展和转移。细胞因子现在被认为是连接炎症和癌症的重要介质，因此是潜在的治疗和预防靶点以及预后因素。白细胞介素（IL）-6细胞因子家族，尤其是IL-6和IL-11，在许多癌症中高度上调，被认为是肿瘤发生和转移过程中最重要的细胞因子家族之一。本综述讨论了将IL-6细胞因子家族与实体恶性肿瘤及其治疗联系起来的分子机制。
Zotero 插件