Maylin Sarah, de Verdière Nathalie Colin, Salmona Maud, Simon François, Delaugerre Constance
Service de Microbiologie, University Paris Diderot, Hôpital Saint Louis, Paris, 75010 Paris, France.
Service de Maladies Infectieuses, University Paris Diderot, Hôpital Saint Louis, 75010 Paris, France.
J Infect Chemother. 2014 Jun;20(6):384-6. doi: 10.1016/j.jiac.2014.01.006. Epub 2014 Mar 6.
No data are available for the kinetics of anti-Hepatitis C Virus (HCV) antibodies in HIV/HCV co-infected patients after sustained virological response (SVR). We present a case of a HIV/HCV co-infected patient, showing a significant anti-HCV antibodies decrease during therapy, who achieved a HCV seroreversion 3 years after SVR. Among them, antibodies to core protein, the most strongly antigenic protein showed significant decrease. Our results indicate an absence of antigenic stimulation suggesting a total clearance of HCV.
关于HIV/HCV合并感染患者在持续病毒学应答（SVR）后抗丙型肝炎病毒（HCV）抗体的动力学，目前尚无可用数据。我们报告了一例HIV/HCV合并感染患者，该患者在治疗期间抗HCV抗体显著下降，并在SVR后3年实现了HCV血清学逆转。其中，针对核心蛋白（抗原性最强的蛋白）的抗体显著下降。我们的结果表明不存在抗原刺激，提示HCV已被完全清除。
