Emiliani Francesco E, Sedlak Thomas W, Sawa Akira
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Curr Opin Psychiatry. 2014 May;27(3):185-90. doi: 10.1097/YCO.0000000000000054.
Oxidative stress has become an exciting area of schizophrenia research, and provides ample opportunities and hope for a better understanding of its pathophysiology, which may lead to novel treatment strategies. This review describes how recent methodological advances have allowed the study of oxidative stress to tackle fundamental questions and have provided several conceptual breakthroughs to the field.
Recent human studies support the notion that intrinsic susceptibility to oxidative stress may underlie the pathophysiology of schizophrenia. More than one animal model that may be relevant to study the biology of schizophrenia also shows sign of oxidative stress in the brain.
These advances have made this topic of paramount importance to the understanding of schizophrenia and will play a role in advancing the treatment options. This review covers topics from the classic biochemical studies of human biospecimens to the use of magnetic resonance spectroscopy and novel mouse models, and focuses on highlighting the promising areas of research.
氧化应激已成为精神分裂症研究中一个令人兴奋的领域，为更好地理解其病理生理学提供了充足的机会和希望，这可能会带来新的治疗策略。本综述描述了最近的方法学进展如何使氧化应激研究能够解决基本问题，并为该领域带来了几个概念上的突破。
最近的人体研究支持这样一种观点，即对氧化应激的内在易感性可能是精神分裂症病理生理学的基础。不止一种可能与精神分裂症生物学研究相关的动物模型也显示出大脑中氧化应激的迹象。
这些进展使这个主题对于理解精神分裂症至关重要，并将在推进治疗选择方面发挥作用。本综述涵盖了从对人类生物样本的经典生化研究到磁共振波谱学和新型小鼠模型的应用等主题，并着重强调了有前景的研究领域。
