Zhang Kaiguo, Zou Lijing, Cai Yi
Shenzhen Mental Health Centre, Shenzhen Kangning Hospital, Shenzhen, China.
Front Psychiatry. 2025 Feb 21;16:1505397. doi: 10.3389/fpsyt.2025.1505397. eCollection 2025.
Schizophrenia is a serious psychiatric disorder of multifactorial triggers, with a lifetime prevalence of about 1% in all countries of the world, with a slightly higher prevalence in males than in females, and with a peak incidence between the ages of 15-35 years old, and a poor prognosis for most of the patients, which imposes a heavy burden on the society and the family. Early intervention is important for the prognosis and regression of patients. More and more studies have found that the imbalance of oxidation and antioxidant, and the persistent damage to the brain by oxidative stress play an important role in the occurrence and development of schizophrenia. Antioxidants, as additive therapy, play an important role in improving symptoms as well as preventing relapse in patients with schizophrenia. This paper intends to address the pathogenesis of oxidative stress injury and schizophrenia, and the significance of oxidative stress in the treatment of schizophrenia.
精神分裂症是一种由多因素触发的严重精神障碍，在世界各国的终生患病率约为1%，男性患病率略高于女性，发病高峰在15至35岁之间，大多数患者预后较差，给社会和家庭带来沉重负担。早期干预对患者的预后和康复很重要。越来越多的研究发现，氧化与抗氧化失衡以及氧化应激对大脑的持续损伤在精神分裂症的发生和发展中起重要作用。抗氧化剂作为辅助治疗，在改善精神分裂症患者症状以及预防复发方面发挥着重要作用。本文旨在探讨氧化应激损伤与精神分裂症的发病机制，以及氧化应激在精神分裂症治疗中的意义。
