Park Hye-Lim, Shim Seung-Hyun, Lee Eun-Young, Cho Whajung, Park Sooho, Jeon Hyun-Jung, Ahn Sun-Young, Kim Hun, Nam Jae-Hwan
Department of Biotechnology; The Catholic University of Korea; Gyeonggi-do, South Korea.
SK Chemical; Sampyeong-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea.
Hum Vaccin Immunother. 2014;10(5):1181-6. doi: 10.4161/hv.28332. Epub 2014 Mar 10.
The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that were immunized with 2 types of influenza virus vaccines-cell culture-based vaccines and egg-based vaccines. HFD mice showed lower levels of neutralizing antibody titers as compared with RFD mice. Moreover, HFD mice showed high levels of MCP-1 in serum and adipocytes, and low level of influenza virus-specific effector memory CD8(+) T cells. After challenge with influenza virus, the lungs of HFD mice showed more severe inflammatory responses as compared with the lungs of RFD mice, even after vaccination. Taken together, our data suggested that the inflammatory condition in obesity may contribute to the suppressed efficacy of influenza vaccination.
肥胖与疫苗效力之间的关系是一个严重问题。先前的研究表明，肥胖者的疫苗效力低于非肥胖者。在此，我们使用高脂饮食（HFD）小鼠和正常脂肪饮食（RFD）小鼠，并用两种流感病毒疫苗——基于细胞培养的疫苗和基于鸡蛋的疫苗进行免疫，研究了肥胖对流感疫苗效力的影响。与RFD小鼠相比，HFD小鼠的中和抗体滴度较低。此外，HFD小鼠血清和脂肪细胞中的MCP-1水平较高，而流感病毒特异性效应记忆CD8(+) T细胞水平较低。在用流感病毒攻击后，即使接种了疫苗，HFD小鼠的肺部炎症反应也比RFD小鼠的肺部更严重。综上所述，我们的数据表明，肥胖中的炎症状态可能导致流感疫苗效力受到抑制。
