Sherman Karen J, Cook Andrea J, Wellman Robert D, Hawkes Rene J, Kahn Janet R, Deyo Richard A, Cherkin Daniel C
Group Health Research Institute, Seattle, Washington.
Ann Fam Med. 2014 Mar-Apr;12(2):112-20. doi: 10.1370/afm.1602.
This trial was designed to evaluate the optimal dose of massage for individuals with chronic neck pain.
We recruited 228 individuals with chronic nonspecific neck pain from an integrated health care system and the general population, and randomized them to 5 groups receiving various doses of massage (a 4-week course consisting of 30-minute visits 2 or 3 times weekly or 60-minute visits 1, 2, or 3 times weekly) or to a single control group (a 4-week period on a wait list). We assessed neck-related dysfunction with the Neck Disability Index (range, 0-50 points) and pain intensity with a numerical rating scale (range, 0-10 points) at baseline and 5 weeks. We used log-linear regression to assess the likelihood of clinically meaningful improvement in neck-related dysfunction (≥5 points on Neck Disability Index) or pain intensity (≥30% improvement) by treatment group.
After adjustment for baseline age, outcome measures, and imbalanced covariates, 30-minute treatments were not significantly better than the wait list control condition in terms of achieving a clinically meaningful improvement in neck dysfunction or pain, regardless of the frequency of treatments. In contrast, 60-minute treatments 2 and 3 times weekly significantly increased the likelihood of such improvement compared with the control condition in terms of both neck dysfunction (relative risk = 3.41 and 4.98, P = .04 and .005, respectively) and pain intensity (relative risk = 2.30 and 2.73; P = .007 and .001, respectively).
After 4 weeks of treatment, we found multiple 60-minute massages per week more effective than fewer or shorter sessions for individuals with chronic neck pain. Clinicians recommending massage and researchers studying this therapy should ensure that patients receive a likely effective dose of treatment.
本试验旨在评估针对慢性颈部疼痛患者的最佳按摩剂量。
我们从一个综合医疗保健系统和普通人群中招募了228名患有慢性非特异性颈部疼痛的个体,并将他们随机分为5组,分别接受不同剂量的按摩(为期4周的疗程,包括每周2次或3次30分钟的就诊,或每周1次、2次或3次60分钟的就诊),或分为一个单一的对照组(在等待名单上为期4周)。我们在基线和5周时使用颈部残疾指数(范围为0 - 50分)评估与颈部相关的功能障碍,并使用数字评分量表(范围为0 - 10分)评估疼痛强度。我们使用对数线性回归来评估治疗组在颈部相关功能障碍(颈部残疾指数提高≥5分)或疼痛强度(改善≥30%)方面实现临床意义上改善的可能性。
在对基线年龄、结局指标和不平衡协变量进行调整后,无论治疗频率如何,30分钟的治疗在实现颈部功能障碍或疼痛的临床意义上的改善方面并不比等待名单对照组显著更好。相比之下,每周进行2次和3次60分钟的治疗与对照组相比,在颈部功能障碍(相对风险分别为3.41和4.98,P分别为0.04和0.005)和疼痛强度(相对风险分别为2.30和2.73;P分别为0.007和0.001)方面显著增加了这种改善的可能性。
经过4周的治疗,我们发现对于慢性颈部疼痛患者,每周多次60分钟的按摩比次数较少或疗程较短的按摩更有效。推荐按摩的临床医生和研究该疗法的研究人员应确保患者接受可能有效的治疗剂量。