烯丙基酮与硼酸酯的氧化交叉偶联：高取代呋喃的快速合成。
Oxidative cross-coupling of allenyl ketones and organoboronic acids: expeditious synthesis of highly substituted furans.
机构信息
Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871 (China).
出版信息
Angew Chem Int Ed Engl. 2014 Apr 7;53(15):3917-21. doi: 10.1002/anie.201400500. Epub 2014 Mar 11.
PMID:24615951
Abstract
Allenyl ketones are employed as coupling partners in palladium-catalyzed oxidative cross-coupling reactions with organoboronic acids. This reaction constitutes an efficient methodology for the synthesis of highly substituted furan derivatives. Palladium-carbene migratory insertion is proposed as the key step in this transformation.
摘要
烯丙基酮可用作钯催化的与有机硼酸的氧化交叉偶联反应中的偶联伙伴。该反应是合成高取代呋喃衍生物的有效方法。钯-卡宾迁移插入被提出是该转化中的关键步骤。
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