Serban G
J Clin Psychiatry. 1978 Feb;39(2):111-6.
The limitation of the methadone maintenance program has pressed for a re-evaluation of our understanding of the underlying causes of addiction. Apparently, one of theunderlying causes or end result produced by the drug itself is that of depression. It explains why the addicts try to maintain to the maximum, the euphoric state and are unwilling to rehabilitate. A pilot study was conducted for the treatment of ex-methadone addicts with large dosages of antidepressants and anxiolytics. Out of 117 ex-methadone and soft drug addicts treated with antidepressants and anxiolytics, 46% ex-methadone and 46.3% soft drug abusers failed to become abstinent. The failures were basically related to the management of treatment. The study suggests a possibility for detoxification from methadone and control of relapse by antidepressants and anxiolytics.
美沙酮维持治疗项目的局限性促使我们重新审视对成瘾潜在原因的理解。显然,药物本身产生的潜在原因或最终结果之一是抑郁。这就解释了为什么成瘾者会尽量维持欣快感状态,而不愿戒毒康复。一项针对使用大剂量抗抑郁药和抗焦虑药治疗美沙酮成瘾者的试点研究展开。在117名接受抗抑郁药和抗焦虑药治疗的美沙酮成瘾者及软性毒品滥用者中,46%的美沙酮成瘾者和46.3%的软性毒品滥用者未能实现戒断。治疗失败基本与治疗管理有关。该研究表明,使用抗抑郁药和抗焦虑药有可能实现美沙酮脱毒及控制复吸。