Kim Ja Hyeong, Jeong Kyoung-Sook, Ha Eun-Hee, Park Hyesook, Ha Mina, Hong Yun-Chul, Bhang Soo-Young, Lee Soo-Jeong, Lee Kyung-Yeon, Lee Seon-Ho, Kim Yangho, Kim Min-Ho, Chang Namsoo
Department of Pediatrics, Ulsan University Hospital, University of Ulsan Collage of Medicine, Ulsan, Korea.
Pediatr Pulmonol. 2015 Feb;50(2):155-63. doi: 10.1002/ppul.23025. Epub 2014 Mar 10.
It is uncertain whether folate is risk or preventive factor for allergic and respiratory diseases.
To determine the relationship between maternal or offspring folate status and subsequent development of allergic and respiratory diseases in early childhood.
In total, 917 mother-child pairs from a prospective birth cohort in South Korea were studied. Data regarding the children's allergic and respiratory outcomes were obtained from standardized questionnaires completed by the mothers at postnatal months 6, 12, and 24. Serum folate levels were measured in the mothers at mid- and late-pregnancy, and in their children at 24 months of age. Atopic biomarkers were measured in the cord blood (CB) and at 24 months after birth. Biomarkers and clinical outcomes were analyzed and compared between the mother-child pairs divided into two groups according to median serum folate status at mid- and late-pregnancy.
Serum folate levels during mid-pregnancy were inversely associated with CB eosinophil count (adjusted odds ratio [OR] 0.72, 95% confidence interval [CI], 0.54-0.96) and positively associated with CB interleukin-10 levels (1.47, 1.11-1.94). Maternal folate level above the median value (≥9.5 ng/ml) during mid-pregnancy was associated with a decreased risk for the child of lower respiratory tract infections (LRTIs) at 6 months of age (adjusted OR 0.50, 95% CI 0.28-0.91) and atopic dermatitis (AD) at 24 months (adjusted OR 0.52, 95% CI 0.31-0.88), but not with LRTIs and AD at other ages.
A relatively high maternal serum folate level in mid-pregnancy was associated with a decreased risk of LRTIs and AD in early childhood.
叶酸是过敏性和呼吸道疾病的风险因素还是预防因素尚不确定。
确定母亲或后代的叶酸状态与幼儿期过敏性和呼吸道疾病后续发展之间的关系。
对来自韩国一项前瞻性出生队列的917对母婴进行了研究。有关儿童过敏性和呼吸道疾病结局的数据来自母亲在产后6个月、12个月和24个月填写的标准化问卷。在孕中期和孕晚期测量母亲的血清叶酸水平，并在孩子24个月大时测量其血清叶酸水平。在脐带血（CB）和出生后24个月测量特应性生物标志物。根据孕中期和孕晚期血清叶酸状态中位数将母婴对分为两组，分析并比较两组之间的生物标志物和临床结局。
孕中期血清叶酸水平与CB嗜酸性粒细胞计数呈负相关（调整后的优势比[OR]为0.72，95%置信区间[CI]为0.54-0.96），与CB白细胞介素-10水平呈正相关（1.47，1.11-1.94）。孕中期母亲叶酸水平高于中位数（≥9.5 ng/ml）与孩子在6个月大时患下呼吸道感染（LRTIs）的风险降低（调整后的OR为0.50，95%CI为0.28-0.91）以及在24个月时患特应性皮炎（AD）的风险降低相关（调整后的OR为0.52，95%CI为0.31-0.88），但与其他年龄的LRTIs和AD无关。
孕中期母亲血清叶酸水平相对较高与幼儿期LRTIs和AD的风险降低相关。
