Vital Anne, Vital Claude
Clin Neuropathol. 2014 May-Jun;33(3):172-8. doi: 10.5414/NP300740.
Simultaneous combined superficial peroneal nerve and peroneous brevis muscle biopsy, via the same cutaneous incision, allows examination of several tissue specimens and significantly improves the diagnosis of systemic diseases with peripheral nerve involvement. Vasculitides are certainly the most frequently diagnosed on neuro-muscular biopsies, but this procedure is also well advised to asses a diagnosis of sarcoidosis or amyloidosis. More occasionally, combined nerve and muscle biopsy may reveal an unpredicted diagnosis of cholesterol embolism, intra-vascular lymphoma, or enables complementary diagnosis investigations on mitochondrial cytopathy or storage disease.
通过同一皮肤切口同时进行腓浅神经和腓骨短肌联合活检，能够检查多个组织样本，并显著提高对伴有周围神经受累的全身性疾病的诊断准确性。血管炎无疑是神经肌肉活检中最常被诊断出的疾病，但对于结节病或淀粉样变性的诊断，也强烈建议采用此方法。更罕见的情况是，联合神经和肌肉活检可能会揭示出意料之外的胆固醇栓塞、血管内淋巴瘤的诊断结果，或者有助于对线粒体细胞病或贮积病进行补充性诊断研究。
