Wang Huizhi, Kumar Akhilesh, Lamont Richard J, Scott David A
Oral Health and Systemic Disease, University of Louisville, Louisville, KY 40292, USA.
Oral Health and Systemic Disease, University of Louisville, Louisville, KY 40292, USA; Microbiology and Immunology, University of Louisville, Louisville, KY 40292, USA.
Trends Microbiol. 2014 Apr;22(4):208-17. doi: 10.1016/j.tim.2014.01.009. Epub 2014 Mar 4.
Glycogen synthase kinase 3β (GSK3β) has been shown to be a crucial mediator of the intensity and direction of the innate immune system response to bacterial stimuli. This review focuses on: (i) the central role of GSK3β in the regulation of pathogen-induced inflammatory responses through the regulation of pro- and anti-inflammatory cytokine production, (ii) the extensive ongoing efforts to exploit GSK3β for its therapeutic potential in the control of infectious diseases, and (iii) the increasing evidence that specific pathogens target GSK3β-related pathways for immune evasion. A better understanding of complex bacteria-GSK3β interactions is likely to lead to more effective anti-inflammatory interventions and novel targets to circumvent pathogen colonization and survival.
糖原合酶激酶3β（GSK3β）已被证明是先天免疫系统对细菌刺激作出反应的强度和方向的关键调节因子。本综述重点关注：（i）GSK3β在通过调节促炎和抗炎细胞因子产生来调控病原体诱导的炎症反应中的核心作用；（ii）为利用GSK3β在控制传染病方面的治疗潜力而正在进行的广泛努力；以及（iii）越来越多的证据表明特定病原体靶向与GSK3β相关的途径以实现免疫逃避。更好地理解复杂的细菌-GSK3β相互作用可能会带来更有效的抗炎干预措施以及规避病原体定植和存活的新靶点。
