ETS-1原癌基因中的限制性片段长度多态性。沙特人群与西方人群的比较。
Restriction fragment length polymorphisms in the ETS-1 proto-oncogene. Comparison of Saudi and Western populations.
作者信息
Parkar M H, Seid J M, Rowson J M, Stringer B M, Vencer L J, Aur R J, Goyns M H
机构信息
Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
出版信息
Experientia. 1988 Dec 1;44(11-12):1019-20. doi: 10.1007/BF01939909.
We have cloned part of the ETS 1 proto-oncogene and demonstrated the presence of two polymorphic Sst I restriction sites. A probe derived from one of our clones revealed the presence of 8.3 kb, 9.5 kb and/or 11.5 kb fragments on Southern blots of human DNA samples. The relative frequencies of these alleles appear to be significantly different between Saudi and Western populations, but there are no apparent differences in these frequencies between Saudi non-leukemic and leukemic individuals.
我们克隆了ETS 1原癌基因的部分序列，并证明存在两个多态性Sst I限制性酶切位点。从我们的一个克隆中获得的探针显示，在人类DNA样本的Southern印迹上存在8.3 kb、9.5 kb和/或11.5 kb的片段。这些等位基因的相对频率在沙特人群和西方人群之间似乎有显著差异，但在沙特非白血病个体和白血病个体之间，这些频率没有明显差异。
Zotero 插件