Pinet A, Corot C, Biot N, Eloy R
Department of Radiology, E. Herriot Hospital, Lyon, France.
Invest Radiol. 1988 Sep;23 Suppl 1:S174-7. doi: 10.1097/00004424-198809001-00030.
To evaluate histamine release (HR) following injection of radiocontrast media and to test the predictive value of peak-expiratory-flow rate (PEFR) in detecting high-risk patients, the authors performed in two series 90 intravenous pyelograms (IVPs). In the first group, HR was measured by a fluorometric method after injection of Hexabrix (25 patients) and Iopamiron (25 patients). In the second group, HR measured by a radioimmunoassay, and PEFR measured by a peak flowmeter were investigated after injection of Hexabrix (10 patients), Telebrix (10 patients), Omnipaque (10 patients) and Iopamiron (10 patients). Histamine release in groups 1 and 2, and PEFR in group 2, were not significantly modified by the injection of each radiocontrast media. For the four patients (two per group) who experienced minor allergic side effects, the levels of HR and PEFR were always within the normal ranges.
为评估注射造影剂后的组胺释放（HR）情况，并测试呼气峰值流速（PEFR）在检测高危患者中的预测价值，作者进行了两个系列共90例静脉肾盂造影（IVP）。在第一组中，注射泛影葡胺（25例患者）和碘帕醇（25例患者）后，采用荧光法测量HR。在第二组中，注射泛影葡胺（10例患者）、碘多啥（10例患者）、欧乃派克（10例患者）和碘帕醇（10例患者）后，采用放射免疫法测量HR，用峰值流量计测量PEFR。注射每种造影剂后，第1组和第2组的组胺释放以及第2组的PEFR均无显著变化。对于出现轻微过敏副作用的4例患者（每组2例），HR和PEFR水平始终在正常范围内。
