Grassi Tiziana, Mancini Fabiola, Ciervo Alessandra, Vescio Maria Fenicia, Ghazal Abeer, Ashour Housam, Saleh Ezzeldin, El Zalabani Mahmoud, Donatelli Isabella, El Sawaf Gamal, Rezza Giovanni
National Public Health Institute, Rome, Italy.
J Infect Dev Ctries. 2014 Mar 13;8(3):379-83. doi: 10.3855/jidc.4458.
Acute respiratory infections (ARI) are the leading cause of pediatric morbidity and mortality worldwide. Information about etiological agents of ARI in developing countries is still limited.
Throat swabs collected from children hospitalized with ARI between December 2009 and May 2010 were investigated for Chlamydophila pneumoniae, Mycoplasma pneumoniae, and influenza viruses by molecular analyses.
This study conducted in Alexandria, Egypt, was designed to determine the prevalence of several microorganisms in 156 children hospitalized with ARI. Overall, samples from 76 individuals (49%) were found to be positive for at least one pathogen, and 10 of them were positive for two agents. C. pneumoniae was the most commonly detected agent, followed by M. pneumonia and H1N1 pandemic influenza virus. Positivity for C. pneumoniae was associated with colder months and mild disease of the upper respiratory tract such as laryngitis.
Further studies are needed to identify other possible agents of ARI (e.g., RSV, adenoviruses, other bacterial infections) in this population and to better understand the causal role of atypical bacteria detected in respiratory samples.
急性呼吸道感染（ARI）是全球儿童发病和死亡的主要原因。发展中国家有关ARI病原体的信息仍然有限。
对2009年12月至2010年5月期间因ARI住院的儿童采集的咽拭子进行分子分析，以检测肺炎衣原体、肺炎支原体和流感病毒。
在埃及亚历山大进行的这项研究旨在确定156名因ARI住院儿童中几种微生物的流行情况。总体而言，76名个体（49%）的样本被发现至少对一种病原体呈阳性，其中10人对两种病原体呈阳性。肺炎衣原体是最常检测到的病原体，其次是肺炎支原体和甲型H1N1流感大流行病毒。肺炎衣原体阳性与较寒冷的月份以及上呼吸道轻度疾病如喉炎有关。
需要进一步研究以确定该人群中ARI的其他可能病原体（如呼吸道合胞病毒、腺病毒、其他细菌感染），并更好地了解在呼吸道样本中检测到的非典型细菌的因果作用。
