Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.
Nat Rev Neurosci. 2014 Apr;15(4):250-63. doi: 10.1038/nrn3708. Epub 2014 Mar 12.
Brain function relies on the ability of neurons to communicate with each other. Interneuronal communication primarily takes place at synapses, where information from one neuron is rapidly conveyed to a second neuron. There are two main modalities of synaptic transmission: chemical and electrical. Far from functioning independently and serving unrelated functions, mounting evidence indicates that these two modalities of synaptic transmission closely interact, both during development and in the adult brain. Rather than conceiving synaptic transmission as either chemical or electrical, this article emphasizes the notion that synaptic transmission is both chemical and electrical, and that interactions between these two forms of interneuronal communication might be required for normal brain development and function.
大脑功能依赖于神经元相互交流的能力。神经元间的交流主要发生在突触，在突触处，一个神经元的信息被迅速传递到另一个神经元。突触传递主要有两种方式：化学传递和电传递。越来越多的证据表明，这两种突触传递方式在发育和成年大脑中密切相互作用，而不是独立发挥作用，执行不相关的功能。本文强调突触传递既是化学传递又是电传递，这两种形式的神经元间通讯的相互作用可能是正常大脑发育和功能所必需的，而不是将突触传递视为化学传递或电传递。
