Head and Neck Services, Tata Memorial Hospital, Mumbai, India.
J Surg Oncol. 2014 Jun;109(7):639-44. doi: 10.1002/jso.23583. Epub 2014 Mar 12.
Certain tumor-related factors like thickness increases the risk of nodal metastasis and may affect survival in patients with oral tongue cancers. The objective of this study is to identify those tumor-related prognostic predictors that can potentially influence decision for adjuvant radiotherapy.
A retrospective review of all patients with oral tongue cancers treated primarily by surgery at Tata Memorial Hospital between January 2007 and June 2010. The demographic and commonly reported histopathological features were analyzed for their influence on disease free and overall survival.
Five hundred eighty-six patients were eligible for the study, of which 416 were males and 117 were females. Follow-up details were available for 498 (85%) patients with a median follow-up of 18 months and mean follow-up of 22 months. There were 302 patients who were alive and disease free at the last follow-up. This group had a mean follow-up of 27 months and median follow-up of 27.5 months. Disease recurrences during follow-up were observed in 184 (31%) patients. Sixty-one patients died subsequently. Perineural invasion significantly affected disease free survival (DFS). A tumor thickness of more than 11 mm significantly affected the overall survival (OS).
Other than nodal metastasis, tumor-related factors like thickness and perineural invasion are adverse prognostic factors and can influence survival. These patients, especially in case of early stage cancers, may potentially benefit from postoperative adjuvant radiotherapy.
2b.
某些与肿瘤相关的因素，如肿瘤厚度的增加，会增加淋巴结转移的风险，并可能影响口腔舌癌患者的生存。本研究旨在确定那些可能影响辅助放疗决策的与肿瘤相关的预后预测因素。
对 2007 年 1 月至 2010 年 6 月期间在塔塔纪念医院接受手术治疗的所有口腔舌癌患者进行回顾性分析。分析了人口统计学和常见报告的组织病理学特征对无病生存和总生存的影响。
586 例患者符合研究条件，其中 416 例为男性，117 例为女性。498 例（85%）患者的随访细节可用，中位随访时间为 18 个月，平均随访时间为 22 个月。有 302 例患者在最后一次随访时存活且无疾病，这组患者的平均随访时间为 27 个月，中位随访时间为 27.5 个月。在随访期间观察到 184 例（31%）患者疾病复发。随后有 61 例患者死亡。神经周围侵犯显著影响无病生存（DFS）。肿瘤厚度超过 11mm 显著影响总生存（OS）。
除了淋巴结转移外，肿瘤相关因素如厚度和神经周围侵犯也是不良预后因素，并可能影响生存。这些患者，尤其是早期癌症患者，可能从术后辅助放疗中获益。
2b。
