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神经周围浸润在头颈部鳞状细胞癌生存中的预后作用：一项系统评价和荟萃分析

The Prognostic Role of Perineural Invasion for Survival in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

作者信息

Tao Zhuo-Ying, Chu Guang, Su Yu-Xiong

机构信息

Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

Division of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

出版信息

Cancers (Basel). 2024 Jul 11;16(14):2514. doi: 10.3390/cancers16142514.

DOI:10.3390/cancers16142514
PMID:39061154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274576/
Abstract

The aim of this study was to conduct a comprehensive review of the predictive significance of PNI in HNSCC survival outcomes. A systematic search was conducted across multiple databases, and all studies published in the last decade were screened (Research Registry ID: reviewregistry1853). The included studies were assessed using the Quality in Prognosis Studies tool. Survival outcome data were extracted, combined, and presented as hazard ratios (HR) with a 95% confidence interval (CI). Totally, 74 studies encompassing 27,559 patients were analyzed and revealed a cumulative occurrent rate of 30% for PNI in HNSCC. PNI+ HNSCC patients had a worse overall survival (HR: 1.91, 95% CI: 1.71-2.13), disease-specific survival (HR: 1.79, 95% CI: 1.55-2.07), disease-free survival (HR: 1.82, 95% CI: 1.69-1.96), local recurrence (HR: 2.54, 95% CI: 1.93-3.33), locoregional recurrence (HR: 2.27, 95% CI: 1.82-2.82), locoregional relapse free survival (HR: 1.77, 95% CI: 1.28-2.45), distant metastasis (HR: 1.82, 95% CI: 1.34-2.48), and distant metastasis-free survival (HR: 2.97, 95% CI: 1.82-4.85) compared to those PNI- patients. The available evidence unequivocally establishes PNI as a critical prognostic factor for worse survival in HNSCC patients.

摘要

本研究的目的是全面综述中性粒细胞与淋巴细胞比值（PNI）对头颈部鳞状细胞癌（HNSCC）生存结局的预测意义。我们在多个数据库中进行了系统检索，并筛选了过去十年发表的所有研究（研究注册编号：reviewregistry1853）。使用预后研究质量工具对纳入的研究进行评估。提取、合并生存结局数据，并以风险比（HR）和95%置信区间（CI）的形式呈现。总共分析了74项研究，涵盖27559例患者，结果显示HNSCC中PNI的累积发生率为30%。与PNI阴性的患者相比，PNI阳性的HNSCC患者的总生存期（HR：1.91，95%CI：1.71 - 2.13）、疾病特异性生存期（HR：1.79，95%CI：1.55 - 2.07）、无病生存期（HR：1.82，95%CI：1.69 - 1.96）、局部复发（HR：2.54，95%CI：1.93 - 3.33）、区域复发（HR：2.27，95%CI：1.82 - 2.82）、区域无复发生存期（HR：1.77，95%CI：1.28 - 2.45）、远处转移（HR：1.82，95%CI：1.34 - 2.48）以及无远处转移生存期（HR：2.97，95%CI：1.82 - 4.85）均较差。现有证据明确表明PNI是HNSCC患者生存较差的关键预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/6f1a41d1a834/cancers-16-02514-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/93196463f553/cancers-16-02514-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/4e013b35738a/cancers-16-02514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/a40044a5511f/cancers-16-02514-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/efcc894de2a3/cancers-16-02514-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/6f1a41d1a834/cancers-16-02514-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/93196463f553/cancers-16-02514-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/4e013b35738a/cancers-16-02514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/a40044a5511f/cancers-16-02514-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/efcc894de2a3/cancers-16-02514-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87ab/11274576/6f1a41d1a834/cancers-16-02514-g005.jpg

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