Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla 3001, Querétaro, 76230, México.
J Neurosci. 2014 Mar 12;34(11):3910-23. doi: 10.1523/JNEUROSCI.2679-13.2014.
Gamma (γ) and beta (β) oscillations seem to play complementary functions in the cortico-basal ganglia-thalamo-cortical circuit (CBGT) during motor behavior. We investigated the time-varying changes of the putaminal spiking activity and the spectral power of local field potentials (LFPs) during a task where the rhythmic tapping of monkeys was guided by isochronous stimuli separated by a fixed duration (synchronization phase), followed by a period of internally timed movements (continuation phase). We found that the power of both bands and the discharge rate of cells showed an orderly change in magnitude as a function of the duration and/or the serial order of the intervals executed rhythmically. More LFPs were tuned to duration and/or serial order in the β- than the γ-band, although different values of preferred features were represented by single cells and by both bands. Importantly, in the LFPs tuned to serial order, there was a strong bias toward the continuation phase for the β-band when aligned to movements, and a bias toward the synchronization phase for the γ-band when aligned to the stimuli. Our results suggest that γ-oscillations reflect local computations associated with stimulus processing, whereas β-activity involves the entrainment of large putaminal circuits, probably in conjunction with other elements of CBGT, during internally driven rhythmic tapping.
γ 和 β 振荡似乎在运动行为期间在皮质基底节丘脑皮质回路 (CBGT) 中发挥互补作用。我们研究了在猴子有节奏敲击受等时刺激引导的任务期间纹状体尖峰活动和局部场电位 (LFP) 的频谱功率的时变变化，这些刺激由固定持续时间 (同步阶段) 隔开，随后是内部定时运动的时期 (延续阶段)。我们发现，两个频带的功率和细胞的放电率都随着间隔的持续时间和/或顺序呈有序变化，这些间隔是有节奏地执行的。尽管单个细胞和两个频带都代表了不同的值，但β频带比γ频带更能调谐到持续时间和/或顺序。重要的是，在调谐到顺序的 LFP 中，当与运动对齐时，β 波段对延续阶段有很强的偏向，而当与刺激对齐时，γ 波段对同步阶段有很强的偏向。我们的结果表明，γ 振荡反映了与刺激处理相关的局部计算，而 β 活动涉及到在内部驱动的有节奏敲击期间，大纹状体电路的同步，可能与 CBGT 的其他元素一起。
