Nocerino Nunzia, Fulgione Andrea, Iannaccone Marco, Tomasetta Laura, Ianniello Flora, Martora Francesca, Lelli Marco, Roveri Norberto, Capuano Federico, Capparelli Rosanna
Department of Agriculture Special Biotechnology Center Federico II, CeBIOTEC Biotechnology, University of Naples Federico II, Naples, Italy.
Department of Chemistry, G Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Int J Nanomedicine. 2014 Mar 5;9:1175-84. doi: 10.2147/IJN.S55060. eCollection 2014.
The emergence of bacterial strains resistant to antibiotics is a general public health problem. Progress in developing new molecules with antimicrobial properties has been made. In this study, we evaluated the biological activity of a hybrid nanocomposite composed of synthetic biomimetic hydroxyapatite surface-functionalized by lactoferrin (LF-HA). We evaluated the antimicrobial, anti-inflammatory, and antioxidant properties of LF-HA and found that the composite was active against both Gram-positive and Gram-negative bacteria, and that it modulated proinflammatory and anti-inflammatory responses and enhanced antioxidant properties as compared with LF alone. These results indicate the possibility of using LF-HA as an antimicrobial system and biomimetic hydroxyapatite as a candidate for innovative biomedical applications.
对抗生素耐药的细菌菌株的出现是一个普遍的公共卫生问题。在开发具有抗菌特性的新分子方面已取得进展。在本研究中，我们评估了由乳铁蛋白表面功能化的合成仿生羟基磷灰石组成的杂化纳米复合材料（LF-HA）的生物活性。我们评估了LF-HA的抗菌、抗炎和抗氧化特性，发现该复合材料对革兰氏阳性菌和革兰氏阴性菌均有活性，并且与单独的乳铁蛋白相比，它调节促炎和抗炎反应并增强抗氧化特性。这些结果表明将LF-HA用作抗菌系统以及将仿生羟基磷灰石用作创新生物医学应用候选材料的可能性。
