Ehmann Heike M A, Zimmer Andreas, Roblegg Eva, Werzer Oliver
Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens University Graz , 8010 Graz, Austria.
Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens University Graz , 8010 Graz, Austria ; Research Center Pharmaceutical Engineering GmbH, 8010 Graz, Austria.
Cryst Growth Des. 2014 Mar 5;14(3):1386-1391. doi: 10.1021/cg401859p. Epub 2014 Feb 10.
The induction of different crystal morphologies is of crucial importance for many applications. In this work, the preparation of various crystal morphologies within clotrimazole films on glass substrates is demonstrated. Amorphous clotrimazole thin films were transformed via vapor annealing into crystalline structures; highly monodisperse/multidisperse crystallites, spherulite, or dendritic structures were obtained as the solvent was exchanged. X-ray diffraction experiments reveal that the same polymorph is present for all samples but with varying texture. The achieved morphologies are explained in terms of Hansen-solubility parameters and vapor pressures; thus, the different morphologies and crystal orientations can be explained by solvent-solid interaction strengths within the thin film samples.
诱导不同的晶体形态对于许多应用至关重要。在这项工作中，展示了在玻璃基板上的克霉唑薄膜内制备各种晶体形态的方法。非晶态克霉唑薄膜通过气相退火转变为晶体结构；随着溶剂的交换，获得了高度单分散/多分散的微晶、球晶或树枝状结构。X射线衍射实验表明，所有样品都存在相同的多晶型物，但织构不同。根据汉森溶解度参数和蒸气压对所获得的形态进行了解释；因此，不同的形态和晶体取向可以通过薄膜样品内的溶剂-固体相互作用强度来解释。
