Ehmann Heike M A, Baumgartner Ramona, Kunert Birgit, Zimmer Andreas, Roblegg Eva, Werzer Oliver
Institute of Pharmaceutical Science, Department of Pharmaceutical Technology, University of Graz , 8010 Graz, Austria.
Research Center Pharmaceutical Engineering GmbH, 8010 Graz, Austria.
J Phys Chem C Nanomater Interfaces. 2014 Jun 19;118(24):12855-12861. doi: 10.1021/jp502330e. Epub 2014 May 27.
The controlled preparation of different crystal morphologies with varying preferential orientation with respect to the substrate is of crucial importance in many fields of applications. In this work, the controlled preparation of different phenytoin morphologies and the dependency of the preferential orientation of those crystallites is related with the preparation method (solvent annealing vs drop casting), as well as the physical-chemical interaction with the solvents in use. While solvent annealing induces the formation of particular structures that are partially dewetted, the drop casting technique from various solvent results in the formation of needle-like and elongated structures, with each having a distinct morphology. The morphologies are explained via the Hansen solubility parameters and correlated with the solvent vapor pressures. X-ray diffraction experiments reveal preferential orientations with respect to the solid substrate and indicate the surface-mediated stabilization of an unknown polymorph of phenytoin with an elongated unit cell in the -axis.
在许多应用领域中，控制制备具有相对于基底不同择优取向的不同晶体形态至关重要。在这项工作中，不同苯妥英形态的控制制备以及这些微晶择优取向的依赖性与制备方法（溶剂退火与滴铸）以及与所用溶剂的物理化学相互作用有关。虽然溶剂退火诱导形成部分去湿的特定结构，但来自各种溶剂的滴铸技术会导致形成针状和细长结构，每种结构都具有独特的形态。通过汉森溶解度参数对形态进行了解释，并与溶剂蒸气压相关联。X射线衍射实验揭示了相对于固体基底的择优取向，并表明在 -轴上具有细长晶胞的苯妥英未知多晶型物的表面介导稳定化。
