Institute for Solid State Physics, NAWI Graz, Graz University of Technology, 8010, Graz, Austria.
Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, University of Graz, 8010, Graz, Austria.
Sci Rep. 2018 May 8;8(1):7134. doi: 10.1038/s41598-018-24238-w.
Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor Deposition (iCVD). This technique allows for solvent-free processing under mild conditions, thus minimizing a potential impact on the pharmaceutical. The drug release behavior, among other properties, was evaluated for polymers of different compositions and at different temperatures. The data show that the release kinetics can be tuned by several orders of magnitude as the cross-linker fraction is varied in the polymer coating. While uncoated indomethacin films were fully released within an hour, polymer coatings showed gradual liberation over several hours to days. Additional insight is gained from evaluating the experimental dissolution data in the framework of diffusive transport. The results of this study show that the iCVD technique has some promises for pharmaceutical technology, potentially allowing for tailored release behavior also for other drug systems.
气相沉积聚合物涂层应用于薄吲哚美辛薄膜上，以改变药物释放。通过引发化学气相沉积（iCVD），直接在溶液浇铸的吲哚美辛薄膜顶部制备 2-羟乙基甲基丙烯酸酯和乙二醇二甲基丙烯酸酯的水凝胶形成共聚物。该技术允许在温和条件下无溶剂处理，从而最大程度地减少对药物的潜在影响。研究了不同组成和不同温度下的聚合物的药物释放行为和其他性能。数据表明，通过改变聚合物涂层中的交联剂分数，可以将释放动力学调节几个数量级。虽然未涂层的吲哚美辛薄膜在一小时内完全释放，但聚合物涂层在数小时至数天内逐渐释放。通过在扩散传输框架中评估实验溶解数据，可以获得更多的见解。这项研究的结果表明，iCVD 技术在制药技术方面具有一定的前景，有可能为其他药物系统也实现定制的释放行为。
