Wang Xiao-Qiang, Huang Ming-Zhu, Zhang Hua, Sun Feng-Bing, Tao Bang-Bao, Feng Bao-Hui, Liao Chen-Long, Kochanski Ryan, Hua Xu-Ming, Li Shi-Ting
From the *Department of Neurosurgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine; †Department of Oncology, Fudan University Shanghai Cancer Center; ‡Department of Ultrasound Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; and §Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI.
J Comput Assist Tomogr. 2014 Mar-Apr;38(2):200-8. doi: 10.1097/RCT.0000000000000018.
Clear cell meningioma (CCM) is a rare meningioma, with radiologic features not well characterized in literature. The purpose of this study was to describe and characterize the clinical features and imaging findings of CCM.
The computed tomography (n = 16) and magnetic resonance (n = 23) images of 23 patients (12 men and 11 women; mean age, 34.6 years) were retrospectively reviewed. All of the patients underwent surgical resection. Follow-up was performed through clinical observations.
Cerebellopontine angle was the most frequently presenting location (n = 10). The tumors were isointense (n = 12) or hypointense but associated with isointense (n = 7) appearance to gray matter on T1-weighted images. However, the tumors seemed to be isointense (n = 6) or isointense and hyperintense (n = 13) on T2-weighted images. On gadolinium-enhanced T1-weighted images, heterogeneous enhancement was seen in 14 lesions. Four lesions had amorphous calcifications, 18 showed peritumoral edema, 14 had cystic areas, 2 had bone hyperostosis, and 8 manifested bone destruction. On initial surgery, 17 patients underwent complete resection, whereas 5 patients underwent subtotal resection of their tumors. The operative result for the remaining patient was unknown. Follow-up was possible in 22 patients. Eleven patients had recurrence and 2 had died.
Clear cell meningioma is a rare subtype of meningioma that occurs in younger patients and often recurs. Cerebellopontine angle is the most affected area in this series. The extent of initial surgical resection is the most important prognostic factor. In radiological studies, CCM tends to have marked heterogeneous enhancement, prominent peritumoral edema, intratumoral cystic components, and involvement of the adjacent bone.
透明细胞型脑膜瘤（CCM）是一种罕见的脑膜瘤，其放射学特征在文献中描述较少。本研究的目的是描述和表征CCM的临床特征及影像学表现。
回顾性分析23例患者（12例男性，11例女性；平均年龄34.6岁）的计算机断层扫描（n = 16）和磁共振成像（n = 23）图像。所有患者均接受了手术切除。通过临床观察进行随访。
桥小脑角是最常见的发病部位（n = 10）。在T1加权图像上，肿瘤呈等信号（n = 12）或低信号但与灰质等信号（n = 7）。然而，在T2加权图像上，肿瘤似乎呈等信号（n = 6）或等信号及高信号（n = 13）。在钆增强T1加权图像上，14个病灶可见不均匀强化。4个病灶有不定形钙化，18个有瘤周水肿，14个有囊性区域，2个有骨质增生，8个有骨质破坏。初次手术时，17例患者肿瘤完全切除，5例患者肿瘤次全切除。其余1例患者的手术结果未知。22例患者可进行随访。11例患者复发，2例患者死亡。
透明细胞型脑膜瘤是脑膜瘤的一种罕见亚型，好发于年轻患者，且常复发。桥小脑角是本研究系列中最常受累的区域。初次手术切除范围是最重要的预后因素。在影像学研究中，CCM往往有明显的不均匀强化、显著的瘤周水肿、瘤内囊性成分及邻近骨质受累。
