Tokumaru A, O'uchi T, Eguchi T, Kawamoto S, Kokubo T, Suzuki M, Kameda T
Department of Diagnostic Radiology, Kameda General Hospital, Chiba, Japan.
Radiology. 1990 May;175(2):431-3. doi: 10.1148/radiology.175.2.2326470.
To assess tissue changes responsible for enhancement of the meninges adjacent to meningiomas on magnetic resonance (MR) images, the authors correlated the MR imaging characteristics of meningeal lesions seen before and after administration of gadolinium diethylenetriamine-pentaacetic acid (DTPA) with the appearance of these lesions on contrast material-enhanced computed tomographic (CT) images and with histopathologic findings in four patients. Histopathologic examination of meninges showed increased loose connective tissue, hypervascularity, and dilated vessels. There was neoplastic infiltration of the dura mater in two patients but it was restricted to the immediate junction of neoplasm and dura mater, with maximum peripheral extension within 1 mm of the tumor margin. In both patients the meninges were enhanced far beyond the neoplastic infiltration. The other two patients showed no infiltration of dura mater. These findings suggest that pathologic enhancement of meninges adjacent to meningioma after administration of Gd-DTPA mainly represents reactive changes to the neoplasm and does not necessarily indicate neoplastic involvement.
为了评估磁共振（MR）图像上脑膜瘤附近脑膜强化的组织学改变，作者将钆喷酸葡胺（DTPA）给药前后观察到的脑膜病变的MR成像特征与这些病变在对比剂增强计算机断层扫描（CT）图像上的表现以及4例患者的组织病理学结果进行了关联。脑膜的组织病理学检查显示疏松结缔组织增多、血管增生和血管扩张。2例患者存在硬脑膜肿瘤浸润，但仅限于肿瘤与硬脑膜的直接交界处，最大外周延伸在肿瘤边缘1毫米以内。在这2例患者中，脑膜强化范围远远超过肿瘤浸润范围。另外2例患者未显示硬脑膜浸润。这些发现表明，给予钆喷酸葡胺后脑膜瘤附近脑膜的病理性强化主要代表对肿瘤的反应性改变，不一定表明肿瘤累及。
