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Genome Sequences of Sequence Type 45 (ST45) Persistent Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia Strain 300-169 and ST45 Resolving MRSA Bacteremia Strain 301-188.序列类型45（ST45）持续性耐甲氧西林金黄色葡萄球菌（MRSA）菌血症菌株300 - 169和ST45解消性MRSA菌血症菌株301 - 188的基因组序列
Genome Announc. 2014 Mar 13;2(2):e00174-14. doi: 10.1128/genomeA.00174-14.
2
Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Sepsis Outcome Programme (ASSOP) Annual Report 2017.澳大利亚抗菌药物耐药性小组（AGAR）澳大利亚金黄色葡萄球菌败血症结局项目（ASSOP）2017年年报。
Commun Dis Intell (2018). 2019 Sep 16;43. doi: 10.33321/cdi.2019.43.43.
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Global Epidemiology and Evolutionary History of Staphylococcus aureus ST45.金黄色葡萄球菌 ST45 的全球流行病学与进化史。
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Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Sepsis Outcome Programme (ASSOP) Annual Report 2018.澳大利亚抗菌药物耐药性小组（AGAR）澳大利亚金黄色葡萄球菌败血症结局项目（ASSOP）2018年年度报告。
Commun Dis Intell (2018). 2020 Mar 16;44. doi: 10.33321/cdi.2020.44.18.
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Molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from patients with bacteremia based on MLST, SCCmec, spa, and agr locus types analysis.基于多位点序列分型（MLST）、葡萄球菌染色体盒式 mec 元件（SCCmec）、葡萄球菌蛋白 A（spa）基因分型及 A 群链球菌调节基因（agr）位点分型分析，对从菌血症患者中分离出的耐甲氧西林金黄色葡萄球菌（MRSA）菌株的分子特征进行研究。
Microb Pathog. 2017 Mar;104:328-335. doi: 10.1016/j.micpath.2017.01.055. Epub 2017 Feb 1.
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Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Sepsis Outcome Programme (ASSOP) Annual Report 2019.澳大利亚抗菌药物耐药性专家组（AGAR）澳大利亚金黄色葡萄球菌脓毒症结局项目（ASSOP）2019 年度报告。
Commun Dis Intell (2018). 2020 Sep 15;44. doi: 10.33321/cdi.2020.44.71.
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Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates.组合表型特征可区分耐甲氧西林金黄色葡萄球菌菌血症分离株的持续性与缓解性。
Antimicrob Agents Chemother. 2011 Feb;55(2):575-82. doi: 10.1128/AAC.01028-10. Epub 2010 Nov 22.
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Role of Purine Biosynthesis in Persistent Methicillin-Resistant Staphylococcus aureus Infection.嘌呤生物合成在耐甲氧西林金黄色葡萄球菌持续感染中的作用。
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A multicentre outbreak of ST45 MRSA containing deletions in the spa gene in New South Wales, Australia.澳大利亚新南威尔士州发生的一起含spa基因缺失的ST45型耐甲氧西林金黄色葡萄球菌多中心暴发。
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Antibiotics (Basel). 2025 Feb 13;14(2):191. doi: 10.3390/antibiotics14020191.
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Gp05, a Prophage-Encoded Virulence Factor, Contributes to Persistent Methicillin-Resistant Staphylococcus aureus Endovascular Infection.Gp05，一种噬菌体编码的毒力因子，有助于耐甲氧西林金黄色葡萄球菌持续性血管内感染。
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mSystems. 2020 Jun 30;5(3):e00178-20. doi: 10.1128/mSystems.00178-20.
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Phenotypic and Genotypic Characteristics of Methicillin-Resistant (MRSA) Related to Persistent Endovascular Infection.与持续性血管内感染相关的耐甲氧西林金黄色葡萄球菌（MRSA）的表型和基因型特征
Antibiotics (Basel). 2019 May 29;8(2):71. doi: 10.3390/antibiotics8020071.
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Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection and the molecular characteristics of MRSA bacteraemia over a two-year period in a tertiary teaching hospital in Malaysia.马来西亚一家三级教学医院两年内耐甲氧西林金黄色葡萄球菌（MRSA）感染的患病率及MRSA菌血症的分子特征
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本文引用的文献

1
De novo finished 2.8 Mbp Staphylococcus aureus genome assembly from 100 bp short and long range paired-end reads.从头组装完成了 2.8 Mbp 的金黄色葡萄球菌基因组，使用的是 100 bp 短读长和长读长配对末端 reads。
Bioinformatics. 2014 Jan 1;30(1):40-9. doi: 10.1093/bioinformatics/btt590. Epub 2013 Oct 15.
2
Analysis of prophages harbored by the human-adapted subpopulation of Staphylococcus aureus CC398.分析适应人类的金黄色葡萄球菌 CC398 亚群中所携带的噬菌体。
Infect Genet Evol. 2013 Aug;18:299-308. doi: 10.1016/j.meegid.2013.06.009. Epub 2013 Jun 14.
3
Reduced vancomycin susceptibility in an in vitro catheter-related biofilm model correlates with poor therapeutic outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.在体外导管相关生物膜模型中，万古霉素敏感性降低与耐甲氧西林金黄色葡萄球菌引起的实验性心内膜炎治疗效果不佳相关。
Antimicrob Agents Chemother. 2013 Mar;57(3):1447-54. doi: 10.1128/AAC.02073-12. Epub 2013 Jan 7.
4
Relationship of agr expression and function with virulence and vancomycin treatment outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.实验性耐甲氧西林金黄色葡萄球菌心内膜炎中 agr 表达和功能与毒力及万古霉素治疗结果的关系。
Antimicrob Agents Chemother. 2011 Dec;55(12):5631-9. doi: 10.1128/AAC.05251-11. Epub 2011 Oct 3.
5
In vitro endothelial cell damage is positively correlated with enhanced virulence and poor vancomycin responsiveness in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.在耐甲氧西林金黄色葡萄球菌引起的实验性心内膜炎中，体外血管内皮细胞损伤与增强的毒力和万古霉素反应不良呈正相关。
Cell Microbiol. 2011 Oct;13(10):1530-41. doi: 10.1111/j.1462-5822.2011.01639.x. Epub 2011 Jul 21.
6
Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates.组合表型特征可区分耐甲氧西林金黄色葡萄球菌菌血症分离株的持续性与缓解性。
Antimicrob Agents Chemother. 2011 Feb;55(2):575-82. doi: 10.1128/AAC.01028-10. Epub 2010 Nov 22.
7
Prophages of Staphylococcus aureus Newman and their contribution to virulence.金黄色葡萄球菌纽曼菌株的原噬菌体及其对毒力的贡献。
Mol Microbiol. 2006 Nov;62(4):1035-47. doi: 10.1111/j.1365-2958.2006.05441.x.
8
Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus.达托霉素与标准疗法治疗金黄色葡萄球菌引起的菌血症和心内膜炎的比较。
N Engl J Med. 2006 Aug 17;355(7):653-65. doi: 10.1056/NEJMoa053783.
9
Persistence in Staphylococcus aureus bacteremia: incidence, characteristics of patients and outcome.金黄色葡萄球菌菌血症的持续存在：发病率、患者特征及预后
Scand J Infect Dis. 2006;38(1):7-14. doi: 10.1080/00365540500372846.

序列类型45（ST45）持续性耐甲氧西林金黄色葡萄球菌（MRSA）菌血症菌株300 - 169和ST45解消性MRSA菌血症菌株301 - 188的基因组序列

Genome Sequences of Sequence Type 45 (ST45) Persistent Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia Strain 300-169 and ST45 Resolving MRSA Bacteremia Strain 301-188.

作者信息

Hernandez David, Seidl Kati, Corvaglia Anna-Rita, Bayer Arnold S, Xiong Yan Q, François Patrice

机构信息

Genomic Research Laboratory, University of Geneva Hospitals, Geneva, Switzerland.

出版信息

Genome Announc. 2014 Mar 13;2(2):e00174-14. doi: 10.1128/genomeA.00174-14.

DOI:10.1128/genomeA.00174-14
PMID:24625873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3953194/
Abstract

Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (positive blood cultures after ≥7 days) represents a challenging subset of invasive MRSA infections. The comparison of genome sequences of persistent (300-169) and resolving (301-188) MRSA bacteremia isolates with similar genetic background (sequence type 45 [ST45]) will help us to better understand underlying mechanisms of persistent MRSA bacteremia.

摘要

持续性耐甲氧西林金黄色葡萄球菌（MRSA）菌血症（≥7天后血培养呈阳性）是侵袭性MRSA感染中具有挑战性的一个子集。对具有相似遗传背景（序列类型45 [ST45]）的持续性（300 - 169）和缓解性（301 - 188）MRSA菌血症分离株的基因组序列进行比较，将有助于我们更好地理解持续性MRSA菌血症的潜在机制。