人类真菌病原体的神秘性策略。
The cryptic sexual strategies of human fungal pathogens.
机构信息
Department of Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA.
出版信息
Nat Rev Microbiol. 2014 Apr;12(4):239-51. doi: 10.1038/nrmicro3236.
Abstract
Sexual reproduction is a pervasive attribute of eukaryotic species and is now recognized to occur in many clinically important human fungal pathogens. These fungi use sexual or parasexual strategies for various purposes that can have an impact on pathogenesis, such as the formation of drug-resistant isolates, the generation of strains with increased virulence or the modulation of interactions with host cells. In this Review, we examine the mechanisms regulating fungal sex and the consequences of these programmes for human disease.
摘要
有性生殖是真核生物的普遍特征，现在已被发现在许多临床上重要的人类真菌病原体中存在。这些真菌利用有性或准性策略来实现各种目的，这些目的可能会影响发病机制，例如形成耐药分离株、产生毒力增强的菌株或调节与宿主细胞的相互作用。在这篇综述中，我们研究了调节真菌有性生殖的机制以及这些程序对人类疾病的影响。
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