Li Xinhua, Wilder-Smith Clive H, Kan Mary Enci, Lu Jia, Cao Yang, Wong Reuben K
Neurogastroenterology Research Unit, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Combat Care Laboratory, DSO National Laboratories, Singapore.
Neuro Endocrinol Lett. 2014;35(1):58-63.
Experimental data suggest stress-related cognitive dysfunction may be associated with increased blood-brain-barrier (BBB) permeability secondary to immune activation.
We investigated the relationship between prolonged and intense physical and psychological combat-training stress, immune activation and blood-brain-barrier permeability in 37 healthy male army medical rapid response troops.
Soldiers during intense combat training showed greater self-reported stress, anxiety and depression levels than at rest, as assessed by specific questionnaires. S100B, a marker of BBB permeability, as well as serum cortisol, IL-6 and TNF-α concentrations, were significantly increased in soldiers during combat training compared to rest (all p<0.05). Serum S100B correlated negatively with morning serum cortisol in soldiers during combat training, but not during the rest period (r=-0.387, p<0.05).
We conclude that combat training inducing significant levels of stress, depression and anxiety is accompanied by evidence of increased blood-brain barrier permeability and by increases in systemic pro-inflammatory mediators.
实验数据表明，与应激相关的认知功能障碍可能与免疫激活继发的血脑屏障（BBB）通透性增加有关。
我们调查了37名健康男性军队医疗快速反应部队中长时间高强度身心战斗训练应激、免疫激活与血脑屏障通透性之间的关系。
通过特定问卷评估，与休息时相比，士兵在高强度战斗训练期间自我报告的应激、焦虑和抑郁水平更高。与休息时相比，战斗训练期间士兵的血脑屏障通透性标志物S100B以及血清皮质醇、IL-6和TNF-α浓度显著升高（均p<0.05）。战斗训练期间士兵的血清S100B与早晨血清皮质醇呈负相关，但在休息期间无此相关性（r=-0.387，p<0.05）。
我们得出结论，导致显著应激、抑郁和焦虑水平的战斗训练伴随着血脑屏障通透性增加以及全身促炎介质增加的证据。
