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Recognition of oligonucleotide-encoded T cell epitopes introduced into a gene unrelated to the original antigen.对引入与原始抗原无关基因中的寡核苷酸编码T细胞表位的识别。
J Exp Med. 1989 Jan 1;169(1):297-302. doi: 10.1084/jem.169.1.297.
2
Synthetic peptides as antigens and competitors in recognition by H-2-restricted cytolytic T cells specific for HLA.合成肽作为被H-2限制的、针对HLA的溶细胞性T细胞识别中的抗原和竞争者。
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Mapping of HLA epitopes recognized by H-2-restricted cytotoxic T lymphocytes specific for HLA using recombinant genes and synthetic peptides.利用重组基因和合成肽对由H-2限制的、针对HLA的细胞毒性T淋巴细胞所识别的HLA表位进行定位。
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Competition between unrelated peptides recognized by H-2-Kd restricted T cells.由H-2-Kd限制性T细胞识别的不相关肽之间的竞争。
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HLA-A1 and HLA-A3 T cell epitopes derived from influenza virus proteins predicted from peptide binding motifs.从肽结合基序预测的源自流感病毒蛋白的HLA - A1和HLA - A3 T细胞表位。
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A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and Th epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen.一种多价小基因疫苗，包含来自几种微生物的B细胞、细胞毒性T淋巴细胞和Th表位，可在体内诱导适当反应，并对多种病原体提供保护。
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Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus.通过抗原化免疫球蛋白和流感病毒将相同病毒肽高效加载到II类分子上。
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Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design.重组多表位蛋白中表达的最小表位被加工并呈递给CD8+细胞毒性T细胞：对疫苗设计的启示。
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Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.由插入免疫性自身和非自身蛋白质不同位置的主要组织相容性复合体I类分子限制性病毒T淋巴细胞表位诱导的抗病毒保护性免疫。
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Presentation by a major histocompatibility complex class I molecule of nucleoprotein peptide expressed in two different genes of an influenza virus transfectant.由流感病毒转染细胞的两个不同基因中表达的核蛋白肽的主要组织相容性复合体I类分子呈递。
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10
Differential effects of flanking residues on presentation of epitopes from chimeric peptides.侧翼残基对嵌合肽表位呈递的差异影响。
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本文引用的文献

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Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.从小鼠骨髓瘤肿瘤总RNA中纯化小鼠免疫球蛋白重链信使RNA。
Eur J Biochem. 1980 Jun;107(2):303-14. doi: 10.1111/j.1432-1033.1980.tb06030.x.
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Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.H-2 限制性 T 细胞的抗原识别。I. 无细胞抗原处理。
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H-2-restricted cytolytic T cells specific for HLA can recognize a synthetic HLA peptide.对HLA具有特异性的H-2限制性细胞溶解T细胞能够识别一种合成的HLA肽。
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Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence.细胞毒性T淋巴细胞识别缺乏信号序列的流感血凝素。
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Interaction between a "processed" ovalbumin peptide and Ia molecules.一种“加工过的”卵清蛋白肽与Ia分子之间的相互作用。
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10
Differences in antigen presentation to MHC class I-and class II-restricted influenza virus-specific cytolytic T lymphocyte clones.向MHC I类和II类限制性流感病毒特异性细胞溶解T淋巴细胞克隆呈递抗原的差异。
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对引入与原始抗原无关基因中的寡核苷酸编码T细胞表位的识别。

Recognition of oligonucleotide-encoded T cell epitopes introduced into a gene unrelated to the original antigen.

作者信息

Chimini G, Pala P, Sire J, Jordan B R, Maryanski J L

机构信息

Centre d'Immunologie INSERM, Centre National de Recherche Scientifique de Marseille-Luminy, Marseille, France.

出版信息

J Exp Med. 1989 Jan 1;169(1):297-302. doi: 10.1084/jem.169.1.297.

DOI:10.1084/jem.169.1.297
PMID:2462610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189194/
Abstract

We have previously demonstrated that H-2Kd-restricted CTL specific for HLA-CW3 or HLA-A24 can recognize synthetic peptides corresponding to residues 170-182 of the HLA molecules. Synthetic oligonucleotides encoding region 170-182 of CW3 or A24 were inserted into the influenza nucleoprotein (NP) gene. We demonstrate herein that P815 (H-2d) cells transfected with the NP-oligo recombinant genes are specifically lysed by HLA-specific Kd-restricted CTL clones. Our results imply that there must be a high degree of flexibility for the expression of T cell epitopes in different molecular contexts.

摘要

我们之前已经证明，针对HLA-CW3或HLA-A24的H-2Kd限制性CTL能够识别与HLA分子第170 - 182位残基相对应的合成肽。将编码CW3或A24第170 - 182位区域的合成寡核苷酸插入流感核蛋白（NP）基因。我们在此证明，用NP-寡核苷酸重组基因转染的P815（H-2d）细胞被HLA特异性Kd限制性CTL克隆特异性裂解。我们的结果表明，在不同分子背景下T细胞表位的表达必定具有高度的灵活性。