由插入免疫性自身和非自身蛋白质不同位置的主要组织相容性复合体I类分子限制性病毒T淋巴细胞表位诱导的抗病毒保护性免疫。
Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.
作者信息
Weidt G, Deppert W, Buchhop S, Dralle H, Lehmann-Grube F
机构信息
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Universität Hamburg, Germany.
出版信息
J Virol. 1995 Apr;69(4):2654-8. doi: 10.1128/JVI.69.4.2654-2658.1995.
Abstract
Injection into mice of chimeric proteins consisting of a portion of either the simian virus 40 large tumor antigen or nonstructural protein 1 of influenza A virus or of the murine tumor suppressor p53 on one hand and T-cell epitopes of lymphocytic choriomeningitis virus on the other resulted in antiviral protective immunity, which was independent of the epitopes' position in the protein and the same whether the latter was immunologically nonself or self. Mice of different haplotypes were protected when the corresponding class I molecule-restricted epitopes had been inserted close to each other in one carrier protein.
摘要
将由猿猴病毒40大肿瘤抗原的一部分、甲型流感病毒的非结构蛋白1或鼠类肿瘤抑制因子p53中的一种与淋巴细胞性脉络丛脑膜炎病毒的T细胞表位组成的嵌合蛋白注射到小鼠体内，可产生抗病毒保护性免疫，这种免疫与表位在蛋白中的位置无关，无论该蛋白在免疫上是异己还是自身成分，产生的免疫反应都相同。当相应的I类分子限制性表位在一种载体蛋白中彼此靠近插入时，不同单倍型的小鼠都受到了保护。
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