UNIVERSITY OF BRESCIA.
Blood. 2014 Mar 6;123(10):1433-4. doi: 10.1182/blood-2014-01-548594.
In this issue of Blood, Mleczko-Sanecka et al used a novel approach based n genome-wide RNA interference knockdown technology to identify the genes involved in the regulation of hepcidin. It showed that hepcidin suppression is linked to the control of mitogen stimulation and nutrient status ia components of well-characterized signaling pathways. This indicates novel links between the control of systemic iron homeostasis and critical liver processes such as regeneration, response to injury, carcinogenesis, and nutrient metabolism.
在本期《Blood》中，Mleczko-Sanecka 等人采用了一种新的方法，基于全基因组 RNA 干扰敲低技术，鉴定了参与调节铁调素的基因。研究表明，铁调素的抑制与丝裂原刺激和营养状态的控制有关，涉及到已充分研究的信号通路的组成部分。这表明系统铁稳态的控制与肝脏的关键过程（如再生、对损伤的反应、癌变和营养代谢）之间存在新的联系。
