Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Int J Mol Sci. 2018 Dec 27;20(1):95. doi: 10.3390/ijms20010095.
Demanded as an essential trace element that supports cell growth and basic functions, iron can be harmful and cancerogenic though. By exchanging between its different oxidized forms, iron overload induces free radical formation, lipid peroxidation, DNA, and protein damages, leading to carcinogenesis or ferroptosis. Iron also plays profound roles in modulating tumor microenvironment and metastasis, maintaining genomic stability and controlling epigenetics. in order to meet the high requirement of iron, neoplastic cells have remodeled iron metabolism pathways, including acquisition, storage, and efflux, which makes manipulating iron homeostasis a considerable approach for cancer therapy. Several iron chelators and iron oxide nanoparticles (IONPs) has recently been developed for cancer intervention and presented considerable effects. This review summarizes some latest findings about iron metabolism function and regulation mechanism in cancer and the application of iron chelators and IONPs in cancer diagnosis and therapy.
作为支持细胞生长和基本功能的必需微量元素，铁也可能有害和致癌。通过不同氧化形式的交换，铁过载诱导自由基形成、脂质过氧化、DNA 和蛋白质损伤，导致致癌或铁死亡。铁还在调节肿瘤微环境和转移、维持基因组稳定性和控制表观遗传学方面发挥着深远的作用。为了满足对铁的高要求，肿瘤细胞已经重塑了铁代谢途径，包括摄取、储存和流出，这使得操纵铁平衡成为癌症治疗的一种重要方法。最近已经开发了几种铁螯合剂和氧化铁纳米颗粒 (IONPs) 用于癌症干预，并取得了相当大的效果。本文综述了铁代谢功能和调节机制在癌症中的最新发现，以及铁螯合剂和 IONPs 在癌症诊断和治疗中的应用。
Zotero 插件